Amyloid Beta and Tau Proteins as Therapeutic Targets for Alzheimer’s Disease Treatment : Rethinking the Current Strategy
Joint Authors
Boehm, Jannic
Perry, George
Zhu, Xiongwei
Mondragón-Rodríguez, Siddhartha
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-08
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Alzheimer’s disease (AD) is defined by the concurrence of accumulation of abnormal aggregates composed of two proteins: Amyloid beta (Aβ) and tau, and of cellular changes including neurite degeneration and loss of neurons and cognitive functions.
Based on their strong association with disease, genetically and pathologically, it is not surprising that there has been a focus towards developing therapies against the aggregated structures.
Unfortunately, current therapies have but mild benefit.
With this in mind we will focus on the relationship of synaptic plasticity with Aβ and tau protein and their role as potential targets for the development of therapeutic drugs.
Finally, we will provide perspectives in developing a multifactorial strategy for AD treatment.
American Psychological Association (APA)
Mondragón-Rodríguez, Siddhartha& Perry, George& Zhu, Xiongwei& Boehm, Jannic. 2012. Amyloid Beta and Tau Proteins as Therapeutic Targets for Alzheimer’s Disease Treatment : Rethinking the Current Strategy. International Journal of Alzheimer's Disease،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-486532
Modern Language Association (MLA)
Mondragón-Rodríguez, Siddhartha…[et al.]. Amyloid Beta and Tau Proteins as Therapeutic Targets for Alzheimer’s Disease Treatment : Rethinking the Current Strategy. International Journal of Alzheimer's Disease No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-486532
American Medical Association (AMA)
Mondragón-Rodríguez, Siddhartha& Perry, George& Zhu, Xiongwei& Boehm, Jannic. Amyloid Beta and Tau Proteins as Therapeutic Targets for Alzheimer’s Disease Treatment : Rethinking the Current Strategy. International Journal of Alzheimer's Disease. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-486532
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-486532