NOD Dendritic Cells Stimulated with Lactobacilli Preferentially Produce IL-10 versus IL-12 and Decrease Diabetes Incidence
Joint Authors
Kosiewicz, Michele M.
Parnell, Sarah A.
Alard, Pascale
Hu, Yoon-Hyeon
Manirarora, Jean N.
Source
Clinical and Developmental Immunology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-12
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Dendritic cells (DCs) from NOD mice produced high levels of IL-12 that induce IFNγ-producing T cells involved in diabetes development.
We propose to utilize the microorganism ability to induce tolerogenic DCs to abrogate the proinflammatory process and prevent diabetes development.
NOD DCs were stimulated with Lactobacilli (nonpathogenic bacteria targeting TLR2) or lipoteichoic acid (LTA) from Staphylococcus aureus (TLR2 agonist).
LTA-treated DCs produced much more IL-12 than IL-10 and accelerated diabetes development when transferred into NOD mice.
In contrast, stimulation of NOD DCs with L.
casei favored the production of IL-10 over IL-12, and their transfer decreased disease incidence which anti-IL-10R antibodies restored.
These data indicated that L.
casei can induce NOD DCs to develop a more tolerogenic phenotype via production of the anti-inflammatory cytokine, IL-10.
Evaluation of the relative production of IL-10 and IL-12 by DCs may be a very useful means of identifying agents that have therapeutic potential.
American Psychological Association (APA)
Manirarora, Jean N.& Parnell, Sarah A.& Hu, Yoon-Hyeon& Kosiewicz, Michele M.& Alard, Pascale. 2011. NOD Dendritic Cells Stimulated with Lactobacilli Preferentially Produce IL-10 versus IL-12 and Decrease Diabetes Incidence. Clinical and Developmental Immunology،Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-486533
Modern Language Association (MLA)
Manirarora, Jean N.…[et al.]. NOD Dendritic Cells Stimulated with Lactobacilli Preferentially Produce IL-10 versus IL-12 and Decrease Diabetes Incidence. Clinical and Developmental Immunology No. 2011 (2011), pp.1-12.
https://search.emarefa.net/detail/BIM-486533
American Medical Association (AMA)
Manirarora, Jean N.& Parnell, Sarah A.& Hu, Yoon-Hyeon& Kosiewicz, Michele M.& Alard, Pascale. NOD Dendritic Cells Stimulated with Lactobacilli Preferentially Produce IL-10 versus IL-12 and Decrease Diabetes Incidence. Clinical and Developmental Immunology. 2011. Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-486533
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-486533