Is Hyperopia an Important Risk Factor for PACG in the Dutch Population?—A Case Control Study

Abstract EN

Objectives.

To determine if hyperopia is a risk factor for primary angle-closure glaucoma (PACG) in the Dutch population and to identify other biometrical parameters as risk factors for PACG including axial length (AL), anterior chamber depth (ACD), and k values.

Methods.

The study population consisted of PACG patients that had undergone a laser peripheral iridotomy (LPI).

The control group consisted of age- and gender-matched cataract patients.

The main outcome was hyperopia (spherical equivalent ≥+0.5 dioptres) measured with IOL Master or autorefractor.

Refractive error, ACD, AL, and k values were tested with a Mann-Whitney U test and by logistic regression.

Results.

117 PACG patients and 234 controls were included (mean age = 80 years ± 3.6).

The prevalence of hyperopia in patients and controls was 69.6% and 61.1%, respectively (Fisher’s test P=0.076).

Mann-Whitney U test showed no statistically significant relation with refractive error (P=0.068) or k values (P=0.607).

In contrast, ACD and AL were statistically significant (P<0.001).

Tested with logistic regression, only ACD was a significant predictor of PACG (P<0.001).

Conclusion.

There was no statistically significant correlation between refractive error and PACG.

ACD was strongly correlated, though, with PACG, whereas AL turned out to be a less significant risk factor.