Cu(II) Complexes of Isoniazid Schiff Bases : DNABSA Binding and Cytotoxicity Studies on A549 Cell Line
Joint Authors
Chakraborty, Debjani
Gupta, Sarita
Ramadevi, Pulipaka
Prajapati, Akhilesh
Singh, Rinky
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-21
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
A series of isonicotinoyl hydrazones have been synthesized via template method and were complexed to Cu(II).
The ligands are coordinated to Cu(II) ion through the enolic oxygen and azomethine nitrogen resulting in a square planar geometry.
The CT-DNA and bovine serum albumin binding propensities of the compounds were determined spectrophotometrically, the results of which indicate good binding propensity of complexes to DNA and BSA with high binding constant values.
Furthermore, the compounds have been investigated for their cytotoxicities on A549 human lung cancer cell.
Also the mode of cell death was examined employing various staining techniques and was found to be apoptotic.
American Psychological Association (APA)
Ramadevi, Pulipaka& Singh, Rinky& Prajapati, Akhilesh& Gupta, Sarita& Chakraborty, Debjani. 2014. Cu(II) Complexes of Isoniazid Schiff Bases : DNABSA Binding and Cytotoxicity Studies on A549 Cell Line. Advances in Chemistry،Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-486567
Modern Language Association (MLA)
Ramadevi, Pulipaka…[et al.]. Cu(II) Complexes of Isoniazid Schiff Bases : DNABSA Binding and Cytotoxicity Studies on A549 Cell Line. Advances in Chemistry No. 2014 (2014), pp.1-14.
https://search.emarefa.net/detail/BIM-486567
American Medical Association (AMA)
Ramadevi, Pulipaka& Singh, Rinky& Prajapati, Akhilesh& Gupta, Sarita& Chakraborty, Debjani. Cu(II) Complexes of Isoniazid Schiff Bases : DNABSA Binding and Cytotoxicity Studies on A549 Cell Line. Advances in Chemistry. 2014. Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-486567
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-486567