Biological Safety of Fish (Tilapia) Collagen
Joint Authors
Yamada, Shizuka
Yoshizawa, Yuu
Yanagiguchi, Kajiro
Sugimoto, Kouji
Hayashi, Yoshihiko
Ikeda, Takeshi
Yamamoto, Kouhei
Igawa, Kazunari
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-07
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Marine collagen derived from fish scales, skin, and bone has been widely investigated for application as a scaffold and carrier due to its bioactive properties, including excellent biocompatibility, low antigenicity, and high biodegradability and cell growth potential.
Fish type I collagen is an effective material as a biodegradable scaffold or spacer replicating the natural extracellular matrix, which serves to spatially organize cells, providing them with environmental signals and directing site-specific cellular regulation.
This study was conducted to confirm the safety of fish (tilapia) atelocollagen for use in clinical application.
We performed in vitro and in vivo biological studies of medical materials to investigate the safety of fish collagen.
The extract of fish collagen gel was examined to clarify its sterility.
All present sterility tests concerning bacteria and viruses (including endotoxin) yielded negative results, and all evaluations of cell toxicity, sensitization, chromosomal aberrations, intracutaneous reactions, acute systemic toxicity, pyrogenic reactions, and hemolysis were negative according to the criteria of the ISO and the Ministry of Health, Labour and Welfare of Japan.
The present study demonstrated that atelocollagen prepared from tilapia is a promising biomaterial for use as a scaffold in regenerative medicine.
American Psychological Association (APA)
Yamamoto, Kouhei& Igawa, Kazunari& Sugimoto, Kouji& Yoshizawa, Yuu& Yanagiguchi, Kajiro& Ikeda, Takeshi…[et al.]. 2014. Biological Safety of Fish (Tilapia) Collagen. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-486589
Modern Language Association (MLA)
Yamamoto, Kouhei…[et al.]. Biological Safety of Fish (Tilapia) Collagen. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-486589
American Medical Association (AMA)
Yamamoto, Kouhei& Igawa, Kazunari& Sugimoto, Kouji& Yoshizawa, Yuu& Yanagiguchi, Kajiro& Ikeda, Takeshi…[et al.]. Biological Safety of Fish (Tilapia) Collagen. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-486589
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-486589