Does Intraoperative Ulinastatin Improve Postoperative Clinical Outcomes in Patients Undergoing Cardiac Surgery : A Meta-Analysis of Randomized Controlled Trials
Joint Authors
Huang, Wen-Qi
Li, Qiao-Bo
He, Qiu-Lan
Shu, Hai-Hua
Ye, Fang
Li, Mei-Na
Sun, Lai-Bao
Liu, Wei-Feng
Wei, Ming
Zhong, Fei
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-09
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Introduction.
The systematic meta-analysis of randomized controlled trials (RCTs) evaluated the effects of intraoperative ulinastatin on early-postoperative recovery in patients undergoing cardiac surgery.
Methods.
RCTs comparing intraoperative ulinastatin with placebo in cardiac surgery were searched through PubMed, Cochrane databases, Medline, SinoMed, and the China National Knowledge Infrastructure (1966 to May 20th, 2013).
The primary endpoints included hospital mortality, postoperative complication rate, length of stay in intensive care unit, and extubation time.
The physiological and biochemical parameters illustrating postoperative cardiac and pulmonary function as well as inflammation response were considered as secondary endpoints.
Results.
Fifteen RCTs (509 patients) met the inclusion criteria.
Ulinastatin did not affect hospital mortality, postoperative complication rate, or ICU length of stay but reduced extubation time.
Ulinastatin also increased the oxygenation index on postoperative day 1 and reduced the plasma level of cardiac troponin-I.
Additionally, ulinastatin inhibited the increased level of tumor necrosis factor-alpha, polymorphonuclear neutrophil elastase, interleukin-6, and interleukin-8 associated with cardiac surgery.
Conclusion.
Ulinastatin may be of value for the inhibition of postoperative increased inflammatory agents and most likely provided pulmonary protective effects in cardiac surgery.
However, larger adequately powered RCTs are required to define the clinical effect of ulinastatin on postoperative outcomes in cardiac surgery.
American Psychological Association (APA)
He, Qiu-Lan& Zhong, Fei& Ye, Fang& Wei, Ming& Liu, Wei-Feng& Li, Mei-Na…[et al.]. 2014. Does Intraoperative Ulinastatin Improve Postoperative Clinical Outcomes in Patients Undergoing Cardiac Surgery : A Meta-Analysis of Randomized Controlled Trials. BioMed Research International،Vol. 2014, no. 2014, pp.1-15.
https://search.emarefa.net/detail/BIM-486600
Modern Language Association (MLA)
He, Qiu-Lan…[et al.]. Does Intraoperative Ulinastatin Improve Postoperative Clinical Outcomes in Patients Undergoing Cardiac Surgery : A Meta-Analysis of Randomized Controlled Trials. BioMed Research International No. 2014 (2014), pp.1-15.
https://search.emarefa.net/detail/BIM-486600
American Medical Association (AMA)
He, Qiu-Lan& Zhong, Fei& Ye, Fang& Wei, Ming& Liu, Wei-Feng& Li, Mei-Na…[et al.]. Does Intraoperative Ulinastatin Improve Postoperative Clinical Outcomes in Patients Undergoing Cardiac Surgery : A Meta-Analysis of Randomized Controlled Trials. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-15.
https://search.emarefa.net/detail/BIM-486600
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-486600