The Pathogenesis of Alzheimer's Disease : A Reevaluation of the “Amyloid Cascade Hypothesis”
Author
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-02-07
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The most influential theory to explain the pathogenesis of Alzheimer's disease (AD) has been the “Amyloid Cascade Hypothesis” (ACH) first formulated in 1992.
The ACH proposes that the deposition of β-amyloid (Aβ) is the initial pathological event in AD leading to the formation of senile plaques (SPs) and then to neurofibrillary tangles (NFTs) death of neurons, and ultimately dementia.
This paper examines two questions regarding the ACH: (1) is there a relationship between the pathogenesis of SPs and NFTs, and (2) what is the relationship of these lesions to disease pathogenesis? These questions are examined in relation to studies of the morphology and molecular determinants of SPs and NFTs, the effects of gene mutation, degeneration induced by head injury, the effects of experimentally induced brain lesions, transgenic studies, and the degeneration of anatomical pathways.
It was concluded that SPs and NFTs develop independently and may be the products rather than the causes of neurodegeneration in AD.
A modification to the ACH is proposed which may better explain the pathogenesis of AD, especially of late-onset cases of the disease.
American Psychological Association (APA)
Armstrong, R. A.. 2011. The Pathogenesis of Alzheimer's Disease : A Reevaluation of the “Amyloid Cascade Hypothesis”. International Journal of Alzheimer's Disease،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-486605
Modern Language Association (MLA)
Armstrong, R. A.. The Pathogenesis of Alzheimer's Disease : A Reevaluation of the “Amyloid Cascade Hypothesis”. International Journal of Alzheimer's Disease No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-486605
American Medical Association (AMA)
Armstrong, R. A.. The Pathogenesis of Alzheimer's Disease : A Reevaluation of the “Amyloid Cascade Hypothesis”. International Journal of Alzheimer's Disease. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-486605
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-486605