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Platelet Concentration in Platelet-Rich Plasma Affects Tenocyte Behavior In Vitro
Joint Authors
Dal Mas, Antonella
Dolo, Vincenza
Properzi, Gianfranco
D’Ascenzo, Sandra
Di Francesco, Marianna
Rughetti, Anna
Mancò, Annalisa
Di Stefano, Gabriella
Giusti, Ilaria
Calvisi, Vittorio
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-23
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Since tendon injuries and tendinopathy are a growing problem, sometimes requiring surgery, new strategies that improve conservative therapies are needed.
Platelet-rich plasma (PRP) seems to be a good candidate by virtue of its high content of growth factors, most of which are involved in tendon healing.
This study aimed to evaluate if different concentrations of platelets in PRP have different effects on the biological features of normal human tenocytes that are usually required during tendon healing.
The different platelet concentrations tested (up to 5 × 106 plt/µL) stimulated differently tenocytes behavior; intermediate concentrations (0.5 × 106, 1 × 106 plt/µL) strongly induced all tested processes (proliferation, migration, collagen, and MMPs production) if compared to untreated cells; on the contrary, the highest concentration had inhibitory effects on proliferation and strongly reduced migration abilities and overall collagen production but, at the same time, induced increasing MMP production, which could be counterproductive because excessive proteolysis could impair tendon mechanical stability.
Thus, these in vitro data strongly suggest the need for a compromise between extremely high and low platelet concentrations to obtain an optimal global effect when inducing in vivo tendon healing.
American Psychological Association (APA)
Giusti, Ilaria& D’Ascenzo, Sandra& Mancò, Annalisa& Di Stefano, Gabriella& Di Francesco, Marianna& Rughetti, Anna…[et al.]. 2014. Platelet Concentration in Platelet-Rich Plasma Affects Tenocyte Behavior In Vitro. BioMed Research International،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-486606
Modern Language Association (MLA)
Giusti, Ilaria…[et al.]. Platelet Concentration in Platelet-Rich Plasma Affects Tenocyte Behavior In Vitro. BioMed Research International No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-486606
American Medical Association (AMA)
Giusti, Ilaria& D’Ascenzo, Sandra& Mancò, Annalisa& Di Stefano, Gabriella& Di Francesco, Marianna& Rughetti, Anna…[et al.]. Platelet Concentration in Platelet-Rich Plasma Affects Tenocyte Behavior In Vitro. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-486606
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-486606