Phylogenomic Investigation of Phospholipid Synthesis in Archaea
Joint Authors
López-García, Purificación
Lombard, Jonathan
Moreira, David
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-16
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Archaea have idiosyncratic cell membranes usually based on phospholipids containing glycerol-1-phosphate linked by ether bonds to isoprenoid lateral chains.
Since these phospholipids strongly differ from those of bacteria and eukaryotes, the origin of the archaeal membranes (and by extension, of all cellular membranes) was enigmatic and called for accurate evolutionary studies.
In this paper we review some recent phylogenomic studies that have revealed a modified mevalonate pathway for the synthesis of isoprenoid precursors in archaea and suggested that this domain uses an atypical pathway of synthesis of fatty acids devoid of any acyl carrier protein, which is essential for this activity in bacteria and eukaryotes.
In addition, we show new or updated phylogenetic analyses of enzymes likely responsible for the isoprenoid chain synthesis from their precursors and the phospholipid synthesis from glycerol phosphate, isoprenoids, and polar head groups.
These results support that most of these enzymes can be traced back to the last archaeal common ancestor and, in many cases, even to the last common ancestor of all living organisms.
American Psychological Association (APA)
Lombard, Jonathan& López-García, Purificación& Moreira, David. 2012. Phylogenomic Investigation of Phospholipid Synthesis in Archaea. Archaea،Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-486609
Modern Language Association (MLA)
Lombard, Jonathan…[et al.]. Phylogenomic Investigation of Phospholipid Synthesis in Archaea. Archaea No. 2012 (2012), pp.1-13.
https://search.emarefa.net/detail/BIM-486609
American Medical Association (AMA)
Lombard, Jonathan& López-García, Purificación& Moreira, David. Phylogenomic Investigation of Phospholipid Synthesis in Archaea. Archaea. 2012. Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-486609
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-486609