Assessment of Procalcitonin to Predict Outcome in Hypothermia-Treated Patients after Cardiac Arrest
Joint Authors
Azuaje, Francisco
Gilson, Georges
Max, Martin
Lorang, Christiane
Werer, Christophe
Devaux, Yvan
Stammet, Pascal
Source
Critical Care Research and Practice
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-26
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Objective.
Determine the potential of procalcitonin (PCT) to predict neurological outcome after hypothermia treatment following cardiac arrest.
Methods.
Retrospective analysis of patient data over a 2-year period.
Mortality and neurological outcome of survivors were determined 6 months after cardiac arrest using the Cerebral Performance Category (CPC) score.
Results.
Data from 53 consecutive patients were analyzed.
Median age was 63 (54–71) and 79% were male.
Twenty-seven patients had good outcome (CPC ≤ 2) whereas 26 had severe neurological sequelae or died (CPC 3–5).
At 48 h, after regaining normothermia, PCT was significantly higher in patients with bad outcome compared to those with good outcome: 3.38 (1.10–24.48) versus 0.28 (0–0.75) ng/mL (P<0.001).
PCT values correlated with bad neurological outcome (r=0.54, P=0.00004) and predicted outcome with an area under the curve of 0.84 (95% CI 0.73–0.96).
A cutoff point of 1 ng/mL provided a sensitivity of 85% and a specificity of 81%.
Above a PCT level of 16 ng/mL, no patient regained consciousness.
PCT provided an additive value over simplified acute physiology score II.
Conclusions.
PCT might be an ancillary marker for outcome prediction after cardiac arrest treated by induced hypothermia.
American Psychological Association (APA)
Stammet, Pascal& Devaux, Yvan& Azuaje, Francisco& Werer, Christophe& Lorang, Christiane& Gilson, Georges…[et al.]. 2011. Assessment of Procalcitonin to Predict Outcome in Hypothermia-Treated Patients after Cardiac Arrest. Critical Care Research and Practice،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-486623
Modern Language Association (MLA)
Stammet, Pascal…[et al.]. Assessment of Procalcitonin to Predict Outcome in Hypothermia-Treated Patients after Cardiac Arrest. Critical Care Research and Practice No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-486623
American Medical Association (AMA)
Stammet, Pascal& Devaux, Yvan& Azuaje, Francisco& Werer, Christophe& Lorang, Christiane& Gilson, Georges…[et al.]. Assessment of Procalcitonin to Predict Outcome in Hypothermia-Treated Patients after Cardiac Arrest. Critical Care Research and Practice. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-486623
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-486623