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Immunity to Visceral Leishmaniasis Using Genetically Defined Live-Attenuated Parasites
Joint Authors
Salotra, Poonam
Gannavaram, Sreenivas
Selvapandiyan, Angamuthu
Lakhal-Naouar, Ines
Dey, Ranadhir
Nakhasi, Hira L.
Duncan, Robert
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-09-06
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Leishmaniasis is a protozoan parasitic disease endemic to the tropical and subtropical regions of the world, with three major clinical forms, self-healing cutaneous leishmaniasis (CL), mucocutaneous leishmaniasis (MCL), and visceral leishmaniasis (VL).
Drug treatments are expensive and often result in the development of drug resistance.
No vaccine is available against leishmaniasis.
Subunit Leishmania vaccine immunization in animal models has shown some efficacy but little or none in humans.
However, individuals who recover from natural infection are protected from reinfection and develop life-long protection, suggesting that infection may be a prerequisite for immunological memory.
Thus, genetically altered live-attenuated parasites with controlled infectivity could achieve such memory.
In this paper, we discuss development and characteristics of genetically altered, live-attenuated Leishmania donovani parasites and their possible use as vaccine candidates against VL.
In addition, we discuss the challenges and other considerations in the use of live-attenuated parasites.
American Psychological Association (APA)
Selvapandiyan, Angamuthu& Dey, Ranadhir& Gannavaram, Sreenivas& Lakhal-Naouar, Ines& Duncan, Robert& Salotra, Poonam…[et al.]. 2011. Immunity to Visceral Leishmaniasis Using Genetically Defined Live-Attenuated Parasites. Journal of Tropical Medicine،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-486655
Modern Language Association (MLA)
Selvapandiyan, Angamuthu…[et al.]. Immunity to Visceral Leishmaniasis Using Genetically Defined Live-Attenuated Parasites. Journal of Tropical Medicine No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-486655
American Medical Association (AMA)
Selvapandiyan, Angamuthu& Dey, Ranadhir& Gannavaram, Sreenivas& Lakhal-Naouar, Ines& Duncan, Robert& Salotra, Poonam…[et al.]. Immunity to Visceral Leishmaniasis Using Genetically Defined Live-Attenuated Parasites. Journal of Tropical Medicine. 2011. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-486655
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-486655