Very Low-Dose Risperidone in First-Episode Psychosis : A Safe and Effective Way to Initiate Treatment
Joint Authors
Harrigan, Susy
McGorry, Patrick D.
Cocks, John
Burnett, Peter
Power, Paddy
Lambert, Tim
Source
Schizophrenia Research and Treatment
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-02-07
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Patients experiencing a first psychotic episode have high rates of extrapyramidal symptoms (EPSs) when treated with the doses of neuroleptics used in multiepisode or chronic schizophrenia.
There is some evidence that lower doses may be equally, if not more, effective but less toxic in this population.
Here, we report the results of a biphasic open label trial designed to assess the efficacy, safety, and tolerability of low-dose (2–4 mg/day) risperidone treatment in a group of 96 first-episode nonaffective psychosis patients.
At the end of the trial, 62% of patients met the response criteria although approximately 80% had achieved a response at some time during the study.
Reports of EPS remained low, and there were no dystonic reactions.
We conclude that even at a dose of 2 mg/day, risperidone was highly effective in reducing acute symptomatology in a real world sample of young first-episode psychosis patients.
American Psychological Association (APA)
McGorry, Patrick D.& Cocks, John& Power, Paddy& Burnett, Peter& Harrigan, Susy& Lambert, Tim. 2011. Very Low-Dose Risperidone in First-Episode Psychosis : A Safe and Effective Way to Initiate Treatment. Schizophrenia Research and Treatment،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-486673
Modern Language Association (MLA)
McGorry, Patrick D.…[et al.]. Very Low-Dose Risperidone in First-Episode Psychosis : A Safe and Effective Way to Initiate Treatment. Schizophrenia Research and Treatment No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-486673
American Medical Association (AMA)
McGorry, Patrick D.& Cocks, John& Power, Paddy& Burnett, Peter& Harrigan, Susy& Lambert, Tim. Very Low-Dose Risperidone in First-Episode Psychosis : A Safe and Effective Way to Initiate Treatment. Schizophrenia Research and Treatment. 2011. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-486673
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-486673