Synthesis of Pyrazine Substituted 1,3,4-Thiadiazole Derivatives and Their Anticonvulsant Activity
Joint Authors
Mallesha, Lingappa
Harish, Kikkeri P.
Mohana, Kikkeri Narasimha Shetty
Source
Organic Chemistry International
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-04
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The synthesis of new pyrazine substituted 1,3,4-thiadiazole derivatives was carried out in good yield by the reaction of pyrazine substituted 1,3,4-thiadiazoles with various sulfonyl chlorides.
A chemical structure of all the new compounds was confirmed by 1H NMR and mass spectral data.
The new compounds were screened for their anticonvulsant activity against maximal electroshock (MES) seizure method.
Rotarod method was employed to determine the neurotoxicity.
Few compounds showed significant changes in anticonvulsant activity.
The same compounds showed no neurotoxicity at the maximum dose administered (100 mg/kg).
American Psychological Association (APA)
Harish, Kikkeri P.& Mohana, Kikkeri Narasimha Shetty& Mallesha, Lingappa. 2013. Synthesis of Pyrazine Substituted 1,3,4-Thiadiazole Derivatives and Their Anticonvulsant Activity. Organic Chemistry International،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-486679
Modern Language Association (MLA)
Harish, Kikkeri P.…[et al.]. Synthesis of Pyrazine Substituted 1,3,4-Thiadiazole Derivatives and Their Anticonvulsant Activity. Organic Chemistry International No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-486679
American Medical Association (AMA)
Harish, Kikkeri P.& Mohana, Kikkeri Narasimha Shetty& Mallesha, Lingappa. Synthesis of Pyrazine Substituted 1,3,4-Thiadiazole Derivatives and Their Anticonvulsant Activity. Organic Chemistry International. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-486679
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-486679