The LOX-1 Scavenger Receptor and Its Implications in the Treatment of Vascular Disease
Joint Authors
Freestone, Katie
Twigg, Michael W.
Ponnambalam, Sreenivasan
Homer-Vanniasinkam, Shervanthi
Source
Cardiology Research and Practice
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-19
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Cardiovascular disease is the leading cause of death.
The disease is due to atherosclerosis which is characterized by lipid and fat accumulation in arterial blood vessel walls.
A key causative event is the accumulation of oxidised low density lipoprotein particles within vascular cells, and this is mediated by scavenger receptors.
One such molecule is the LOX-1 scavenger receptor that is expressed on endothelial, vascular smooth muscle, and lymphoid cells including macrophages.
LOX-1 interaction with OxLDL particles stimulates atherosclerosis.
LOX-1 mediates OxLDL endocytosis via a clathrin-independent internalization pathway.
Transgenic animal model studies show that LOX-1 plays a significant role in atherosclerotic plaque initiation and progression.
Administration of LOX-1 antibodies in cellular and animal models suggest that such intervention inhibits atherosclerosis.
Antiatherogenic strategies that target LOX-1 function using gene therapy or small molecule inhibitors would be new ways to address the increasing incidence of vascular disease in many countries.
American Psychological Association (APA)
Twigg, Michael W.& Freestone, Katie& Homer-Vanniasinkam, Shervanthi& Ponnambalam, Sreenivasan. 2012. The LOX-1 Scavenger Receptor and Its Implications in the Treatment of Vascular Disease. Cardiology Research and Practice،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-486745
Modern Language Association (MLA)
Twigg, Michael W.…[et al.]. The LOX-1 Scavenger Receptor and Its Implications in the Treatment of Vascular Disease. Cardiology Research and Practice No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-486745
American Medical Association (AMA)
Twigg, Michael W.& Freestone, Katie& Homer-Vanniasinkam, Shervanthi& Ponnambalam, Sreenivasan. The LOX-1 Scavenger Receptor and Its Implications in the Treatment of Vascular Disease. Cardiology Research and Practice. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-486745
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-486745