Risk of Dementia Associated with Elevated Plasma Homocysteine in a Latin American Population
Joint Authors
Maestre, Gladys E.
Luchsinger, José A.
Lee, Joseph H.
Chacón, Inara J.
Molero, Aldrín E.
Pino-Ramírez, Gloria
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-08-23
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The relationship between total homocysteine (tHcy) and dementia risk remains controversial, as the association varies among populations and dementia subtypes.
We studied a Venezuelan population that has high prevalence of both elevated tHcy and dementia.
We tested the hypotheses that (1) elevated tHcy is associated with increased dementia risk, (2) the risk is greater for vascular dementia (VaD) than for Alzheimer's disease (AD), and (3) a history of stroke may partly explain this association.
2100 participants (≥55 years old) of the Maracaibo Aging Study underwent standardized neurological, neuropsychiatric, and cardiovascular assessments.
Elevated tHcy was significantly associated with dementia, primarily VaD.
When history of stroke and other confounding factors were taken into account, elevated tHcy remained a significant risk factor in older (>66 years), but not in younger (55–66 years) subjects.
Ongoing studies of this population may provide insight into the mechanism by which tHcy increases risk for dementia.
American Psychological Association (APA)
Chacón, Inara J.& Molero, Aldrín E.& Pino-Ramírez, Gloria& Luchsinger, José A.& Lee, Joseph H.& Maestre, Gladys E.. 2009. Risk of Dementia Associated with Elevated Plasma Homocysteine in a Latin American Population. International Journal of Alzheimer's Disease،Vol. 2009, no. 2009, pp.1-6.
https://search.emarefa.net/detail/BIM-486756
Modern Language Association (MLA)
Chacón, Inara J.…[et al.]. Risk of Dementia Associated with Elevated Plasma Homocysteine in a Latin American Population. International Journal of Alzheimer's Disease No. 2009 (2009), pp.1-6.
https://search.emarefa.net/detail/BIM-486756
American Medical Association (AMA)
Chacón, Inara J.& Molero, Aldrín E.& Pino-Ramírez, Gloria& Luchsinger, José A.& Lee, Joseph H.& Maestre, Gladys E.. Risk of Dementia Associated with Elevated Plasma Homocysteine in a Latin American Population. International Journal of Alzheimer's Disease. 2009. Vol. 2009, no. 2009, pp.1-6.
https://search.emarefa.net/detail/BIM-486756
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-486756