Raman Spectroscopic Methods for Classification of Normal and Malignant Hypopharyngeal Tissues : An Exploratory Study
Joint Authors
Pujary, Kailesh
Pujary, Parul
Krishna, C. Murali
Maheedhar, K.
Source
Pathology Research International
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-07-24
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Laryngeal cancer is more common in males.
The present study is aimed at exploration of potential of conventional Raman spectroscopy in classifying normal from a malignant laryngopharyngeal tissue.
We have recorded Raman spectra of twenty tissues (aryepiglottic fold) using an in-house built Raman setup.
The spectral features of mean malignant spectrum suggests abundance proteins whereas spectral features of mean normal spectrum indicate redundancy of lipids.
PCA was employed as discriminating algorithm.
Both, unsupervised and supervised modes of analysis as well as match/mismatch “limit test” methodology yielded clear classification among tissue types.
The findings of this study demonstrate the efficacy of conventional Raman spectroscopy in classification of normal and malignant laryngopharyngeal tissues.
A rigorous evaluation of the models with development of suitable fibreoptic probe may enable real-time Raman spectroscopic diagnosis of laryngopharyngeal cancers in future.
American Psychological Association (APA)
Pujary, Parul& Maheedhar, K.& Krishna, C. Murali& Pujary, Kailesh. 2011. Raman Spectroscopic Methods for Classification of Normal and Malignant Hypopharyngeal Tissues : An Exploratory Study. Pathology Research International،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-486757
Modern Language Association (MLA)
Pujary, Parul…[et al.]. Raman Spectroscopic Methods for Classification of Normal and Malignant Hypopharyngeal Tissues : An Exploratory Study. Pathology Research International No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-486757
American Medical Association (AMA)
Pujary, Parul& Maheedhar, K.& Krishna, C. Murali& Pujary, Kailesh. Raman Spectroscopic Methods for Classification of Normal and Malignant Hypopharyngeal Tissues : An Exploratory Study. Pathology Research International. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-486757
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-486757