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Breast and Ovarian Cancer Risk due to Prevalence of BRCA1 and BRCA2 Variants in Pakistani Population : A Pakistani Database Report
Joint Authors
Ahmad, Tausif
Naveed, Abdul Khaliq
Farooq, Ayesha
Azeem, Zahid
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-03-24
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Introduction.
Pakistani population has a very rich anthrogeneological background with waves of migration from neighboring regions.
Incidence rates of breast and ovarian cancer in Pakistan are on such a rapid rise that it is necessary to check the contributory factors, genetic and nongenetic.
An insight into the prevalence data emphasizes the formulation of a BRCA1 and BRCA2 database for the Pakistani population.
Method.
In this study conducted by authors, data from diagnosed cases of both sporadic and inherited female breast and ovarian cancer cases was gathered after performing molecular genetic analysis by screening for alterations in the coding sequence of the BRCA gene.
The region of interest was analyzed by the aid of various molecular biology tools such as automated DNA sequencer.
Bioinformatics software was used to interpret the results, and database was prepared.
Results.
Mutational screening of the exons in all the samples of our study group did not reveal any pathogenic mutation.
These results along with the results of the previous Pakistani studies for both BRCA1 and BRCA2 genes were summed up to prepare a Pakistani database.
Percentage involvement of these genes was estimated.
Nine percent of these cancers show alterations in BRCA1 gene while 3 percent have shown BRCA2 variants.
The remaining 88 percent of breast and ovarian cancers can be attributed to the involvement of other genes.
American Psychological Association (APA)
Farooq, Ayesha& Naveed, Abdul Khaliq& Azeem, Zahid& Ahmad, Tausif. 2011. Breast and Ovarian Cancer Risk due to Prevalence of BRCA1 and BRCA2 Variants in Pakistani Population : A Pakistani Database Report. Journal of Oncology،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-486799
Modern Language Association (MLA)
Farooq, Ayesha…[et al.]. Breast and Ovarian Cancer Risk due to Prevalence of BRCA1 and BRCA2 Variants in Pakistani Population : A Pakistani Database Report. Journal of Oncology No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-486799
American Medical Association (AMA)
Farooq, Ayesha& Naveed, Abdul Khaliq& Azeem, Zahid& Ahmad, Tausif. Breast and Ovarian Cancer Risk due to Prevalence of BRCA1 and BRCA2 Variants in Pakistani Population : A Pakistani Database Report. Journal of Oncology. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-486799
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-486799