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Oncolytic Virotherapy for Multiple Myeloma : Past, Present, and Future
Joint Authors
Morris, Don G.
Thirukkumaran, Chandini M.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-05-10
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Multiple myeloma (MM) is a B-cell malignancy that is currently felt to be incurable.
Despite recently approved novel targeted treatments such as lenalidomide and bortezomib, most MM patients' relapse is emphasizing the need for effective and well-tolerated therapies for this deadly disease.
The use of oncolytic viruses has garnered significant interest as cancer therapeutics in recent years, and are currently under intense clinical investigation.
Both naturally occurring and engineered DNA and RNA viruses have been investigated preclinically as treatment modalities for several solid and hematological malignancies.
Presently, only a genetically modified measles virus is in human clinical trials for MM.
The information obtained from this and other future clinical trials will guide clinical application of oncolytic viruses as anticancer agents for MM.
This paper provides a timely overview of the history of oncolytic viruses for the treatment of MM and future strategies for the optimization of viral therapy for this disease.
American Psychological Association (APA)
Thirukkumaran, Chandini M.& Morris, Don G.. 2011. Oncolytic Virotherapy for Multiple Myeloma : Past, Present, and Future. Bone Marrow Research،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-486807
Modern Language Association (MLA)
Thirukkumaran, Chandini M.& Morris, Don G.. Oncolytic Virotherapy for Multiple Myeloma : Past, Present, and Future. Bone Marrow Research No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-486807
American Medical Association (AMA)
Thirukkumaran, Chandini M.& Morris, Don G.. Oncolytic Virotherapy for Multiple Myeloma : Past, Present, and Future. Bone Marrow Research. 2011. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-486807
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-486807