Acute Liver Failure Associated with Levetiracetam and Lacosamide Combination Treatment for Unspecified Epileptic Disorder

Abstract EN

Background and Aim.

Levetiracetam is a second-generation antiepileptic drug.

It is approved as an adjunctive treatment of partial onset seizures with or without secondary generalization.

It is considered safe with less than 1% of patients with transient elevations of liver enzymes.

Methods.

We report a case of acute liver failure secondary to Levetiracetam in combination with Lacosamide documented with a liver biopsy.

Results.

Liver biopsy demonstrated acute liver injury with a predominant submassive necrosis pattern and features of a drug-induced hepatitis.

Conclusions.

This is the first published case of acute liver failure due to antiepileptic therapy with Levetiracetam in combination with Lacosamide.