Effect of Angiotensin II on the Left Ventricular Function in a Near-Term Fetal Sheep with Metabolic Acidemia
Joint Authors
Huhta, James C.
How, Ole-Jakob
Acharya, Ganesh
Erkinaro, Tiina
Räsänen, Juha
Haapsamo, Mervi
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-31
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
We tested the hypothesis that, in acute metabolic acidemia, the fetal left ventricle (LV) has the capacity to increase its contractility in response to angiotensin II infusion.
Eleven ewes and their fetuses were instrumented at 127–138/145 days of gestation.
The effect of angiotensin II on fetal LV function was assessed using intraventricular pressure catheter and tissue Doppler imaging (TDI).
Angiotensin II increased fetal arterial blood pressure, whereas pH and pO2 decreased.
The heart rate and systemic venous pressure were not affected significantly.
The LV end-diastolic and end-systolic pressures, as well as dP/dtmax, increased.
The TDI-derived LV longitudinal myocardial isovolumic contraction velocity and its acceleration and velocity during early filling were higher than those at baseline.
The incidence of absent isovolumic relaxation velocity was greater during angiotensin II infusion.
In summary, during acute metabolic acidemia, the fetal left ventricle could increase its contractility in response to inotropic stimulus even in the presence of increased afterload.
The diastolic LV function parameters were altered by angiotensin II.
American Psychological Association (APA)
Acharya, Ganesh& Huhta, James C.& Haapsamo, Mervi& How, Ole-Jakob& Erkinaro, Tiina& Räsänen, Juha. 2011. Effect of Angiotensin II on the Left Ventricular Function in a Near-Term Fetal Sheep with Metabolic Acidemia. Journal of Pregnancy،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-486839
Modern Language Association (MLA)
Acharya, Ganesh…[et al.]. Effect of Angiotensin II on the Left Ventricular Function in a Near-Term Fetal Sheep with Metabolic Acidemia. Journal of Pregnancy No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-486839
American Medical Association (AMA)
Acharya, Ganesh& Huhta, James C.& Haapsamo, Mervi& How, Ole-Jakob& Erkinaro, Tiina& Räsänen, Juha. Effect of Angiotensin II on the Left Ventricular Function in a Near-Term Fetal Sheep with Metabolic Acidemia. Journal of Pregnancy. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-486839
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-486839