Kluyveromyces lactis : A Suitable Yeast Model to Study Cellular Defense Mechanisms against Hypoxia-Induced Oxidative Stress

Abstract EN

Studies about hypoxia-induced oxidative stress in human health disorders take advantage from the use of unicellular eukaryote models.

A widely extended model is the fermentative yeast Saccharomyces cerevisiae.

In this paper, we describe an overview of the molecular mechanisms induced by a decrease in oxygen availability and their interrelationship with the oxidative stress response in yeast.

We focus on the differential characteristics between S.

cerevisiae and the respiratory yeast Kluyveromyces lactis, a complementary emerging model, in reference to multicellular eukaryotes.