Cytotoxic Effect of the Genus Sinularia Extracts on Human SCC25 and HaCaT Cells
Joint Authors
Liang, Chia-Hua
Lin, Rong-Jyh
Wang, Shih-Hao
Wang, Guey-Horng
Sheu, Jyh-Horng
Chou, Tzung-Han
Source
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2008-10-13
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Pharmacy, Health & Medical Sciences
Medicine
Abstract EN
Soft corals of the genus Sinularia are being increasingly adopted to treat a wide variety of disease processes.
However, the mechanism underlying its activity against human oral cancer cells is poorly understood.
This study evaluates the cyototoxicity effects of the genus Sinularia extracts (S.
grandilobata, S.
parva, S.
triangula, S.
scabra, S.
nanolobata and S.
gibberosa) by SCC25 and HaCaT cells.
The cell adhesion assay indicates that extracts reduce the cell attachment.
Extracts exhibit a dose-dependent cytotoxic effect using MTS assay.Treatment of extracts to observe the morphological alterations in cells, membrane blebbing, nuclear condensation, and apoptotic bodies is demonstrated.
Flow cytometry shows that extracts sensitized the cells in the G0/G1 and G2/M phases with a concomitant significantly increased sub-G1 fraction, suggesting cell death by apoptosis.
Extracts of the genus Sinularia thus apparently cause apoptosis of SCC25 and HaCaT cells, and warrant further research investigating the possible antioral cancer compounds in these soft corals.
American Psychological Association (APA)
Wang, Guey-Horng& Chou, Tzung-Han& Lin, Rong-Jyh& Sheu, Jyh-Horng& Wang, Shih-Hao& Liang, Chia-Hua. 2008. Cytotoxic Effect of the Genus Sinularia Extracts on Human SCC25 and HaCaT Cells. Journal of Toxicology،Vol. 2009, no. 2009, pp.1-8.
https://search.emarefa.net/detail/BIM-486896
Modern Language Association (MLA)
Wang, Guey-Horng…[et al.]. Cytotoxic Effect of the Genus Sinularia Extracts on Human SCC25 and HaCaT Cells. Journal of Toxicology No. 2009 (2009), pp.1-8.
https://search.emarefa.net/detail/BIM-486896
American Medical Association (AMA)
Wang, Guey-Horng& Chou, Tzung-Han& Lin, Rong-Jyh& Sheu, Jyh-Horng& Wang, Shih-Hao& Liang, Chia-Hua. Cytotoxic Effect of the Genus Sinularia Extracts on Human SCC25 and HaCaT Cells. Journal of Toxicology. 2008. Vol. 2009, no. 2009, pp.1-8.
https://search.emarefa.net/detail/BIM-486896
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-486896