Angiogenesis and Proliferation Index in Patients with Acute Leukemia : A Prospective Study
Joint Authors
Basu, Debdatta
Dutta, Tarun K.
Jothilingam, Prabhavati
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-31
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Angiogenesis and proliferation as measured by microvessel density (MVD) and proliferation index (PI) are essential correlates of malignancy.
The aim of our study was to evaluate difference between these values in AML and ALL and also to study the modulation in these parameters following achievement of remission in acute lymphoblastic leukemia.
Differences between adult and adolescent cases of acute leukemia in relation to these values were also studied.
We also tried to assess the relationship between angiogenesis and proliferation.
Fifty-five patients with acute leukemia were included in the study.
Trephine biopsies were immunostained with CD34 and factor VIIIrAg to demonstrate angiogenesis measured as MVD.
Immunostaining with PCNA and Ki-67 was done to study proliferation.
We found a significant increase in MVD and PI in cases when compared with controls (P<0.0001).
In addition cases with ALL had a significantly higher MVD compared to those with AML (P<0.01).
The patients with ALL who went into remission showed a significant reduction in MVD; PI remained high.
The cases which did not achieve remission showed no significant reduction in either MVD or PI.
All adolescent cases of ALL were similar to adults with respect to MVD and PI.
American Psychological Association (APA)
Jothilingam, Prabhavati& Basu, Debdatta& Dutta, Tarun K.. 2014. Angiogenesis and Proliferation Index in Patients with Acute Leukemia : A Prospective Study. Bone Marrow Research،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-486897
Modern Language Association (MLA)
Jothilingam, Prabhavati…[et al.]. Angiogenesis and Proliferation Index in Patients with Acute Leukemia : A Prospective Study. Bone Marrow Research No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-486897
American Medical Association (AMA)
Jothilingam, Prabhavati& Basu, Debdatta& Dutta, Tarun K.. Angiogenesis and Proliferation Index in Patients with Acute Leukemia : A Prospective Study. Bone Marrow Research. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-486897
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-486897