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Association of Plasma Homocysteine with Self-Reported Sleep Apnea Is Confounded by Age : Results from the National Health and Nutrition Examination Survey 2005-2006
Joint Authors
Mamtani, Manju
Kulkarni, Hemant
Ujaoney, Shweta
Thakre, Tushar P.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-12-29
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
High levels of plasma homocysteine are implicated in the pathogenesis of cardiovascular diseases especially if accompanied by sleep apnea, but a direct pathogenetic link between plasma homocysteine levels and obstructive sleep apnea is debatable.
This association can have far-reaching public health implications considering the inverse association between folate and plasma homocysteine.
We used data from the 2005-2006 cycle of the National Health and Nutrition Examination Survey (NHANES) to test the hypothesized associations.
Of the 4490 subjects included in analysis, 177 reported sleep apnea.
Age-standardized and design-effect-corrected prevalence rates were differential across gender, plasma homocysteine, and red cell folate status.
Plasma homocysteine was positively correlated with age (r=0.38, P<0.0001).
Multivariate analyses using sociodemographic and clinical covariates demonstrated that plasma homocysteine levels retained their respective associations with self-reported sleep apnea in all models except when age was included as a covariate.
Our results demonstrate that the claimed association of plasma homocysteine with sleep apnea may be confounded by age.
American Psychological Association (APA)
Thakre, Tushar P.& Mamtani, Manju& Ujaoney, Shweta& Kulkarni, Hemant. 2011. Association of Plasma Homocysteine with Self-Reported Sleep Apnea Is Confounded by Age : Results from the National Health and Nutrition Examination Survey 2005-2006. Sleep Disorders،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-486900
Modern Language Association (MLA)
Thakre, Tushar P.…[et al.]. Association of Plasma Homocysteine with Self-Reported Sleep Apnea Is Confounded by Age : Results from the National Health and Nutrition Examination Survey 2005-2006. Sleep Disorders No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-486900
American Medical Association (AMA)
Thakre, Tushar P.& Mamtani, Manju& Ujaoney, Shweta& Kulkarni, Hemant. Association of Plasma Homocysteine with Self-Reported Sleep Apnea Is Confounded by Age : Results from the National Health and Nutrition Examination Survey 2005-2006. Sleep Disorders. 2011. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-486900
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-486900