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Evaluation of Clinical and Immunopathological Features of Different Infective Doses of Trypanosoma cruzi in Dogs during the Acute Phase
Joint Authors
Dumonteil, Eric
Barbosa-Mireles, Marco A.
Cruz-Chan, Julio V.
Vázquez-Chagoyán, Juan C.
Aparicio-Burgos, Esteban
Castro-Barcena, Alejandro
Bolio-González, M. E.
Quijano-Hernández, Israel A.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-01
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Medicine
Information Technology and Computer Science
Abstract EN
Infection with Trypanosoma cruzi is a major risk in Latin America, and dogs are believed to be good models for evaluating Chagas disease.
Here, we evaluated the clinical and immunopathological alterations developed by mongrel dogs experimentally infected with different infective doses (2,000, 20,000, and 200,000 metacyclic trypomastigotes of Sylvio X10/4 strain kg−1 via intraperitoneal).
Clinical and electrocardiographic parameters, as well as antibody production and pathologic lesions were evaluated.
All three doses of this strain of T.
cruzi induced a similar pattern of infection characterized by cardiac arrhythmias and severe and diffuse myocarditis.
Specific anti-T.
cruzi IgG indicated seroconversion by day 14 after infection, and IgG levels increased during the period of evaluation.
Mortality was observed only in dogs infected with the medium or high parasite doses, but not in the group infected with a low dose of 2,000 parasites kg-1.
Infection with a low dose of parasites provides an excellent nonlethal model to evaluate the immunopathology of the acute disease in dogs infected with the Sylvio X10/4 strain of T.
cruzi.
American Psychological Association (APA)
Quijano-Hernández, Israel A.& Castro-Barcena, Alejandro& Aparicio-Burgos, Esteban& Barbosa-Mireles, Marco A.& Cruz-Chan, Julio V.& Vázquez-Chagoyán, Juan C.…[et al.]. 2012. Evaluation of Clinical and Immunopathological Features of Different Infective Doses of Trypanosoma cruzi in Dogs during the Acute Phase. The Scientific World Journal،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-486931
Modern Language Association (MLA)
Quijano-Hernández, Israel A.…[et al.]. Evaluation of Clinical and Immunopathological Features of Different Infective Doses of Trypanosoma cruzi in Dogs during the Acute Phase. The Scientific World Journal No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-486931
American Medical Association (AMA)
Quijano-Hernández, Israel A.& Castro-Barcena, Alejandro& Aparicio-Burgos, Esteban& Barbosa-Mireles, Marco A.& Cruz-Chan, Julio V.& Vázquez-Chagoyán, Juan C.…[et al.]. Evaluation of Clinical and Immunopathological Features of Different Infective Doses of Trypanosoma cruzi in Dogs during the Acute Phase. The Scientific World Journal. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-486931
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-486931