The Hepatoprotective Effect of Sodium Nitrite on Cold Ischemia-Reperfusion Injury
Joint Authors
Patel, Rakesh P.
Meng, Zihui
Lang, John D.
Li, Wei
Liu, Yuliang
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-28
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Liver ischemia-reperfusion injury is a major cause of primary graft non-function or initial function failure post-transplantation.
In this study, we examined the effects of sodium nitrite supplementation on liver IRI in either Lactated Ringer's (LR) solution or University of Wisconsin (UW) solution.
The syngeneic recipients of liver grafts were also treated with or without nitrite by intra-peritoneal injection.
Liver AST and LDH release were significantly reduced in both nitrite-supplemented LR and UW preservation solutions compared to their controls.
The protective effect of nitrite was more efficacious with longer cold preservation times.
Liver histological examination demonstrated better preserved morphology and architecture with nitrite treatment.
Hepatocellular apoptosis was significantly reduced in the nitrite-treated livers compared their controls.
Moreover, liver grafts with extended cold preservation time of 12 to 24 hours demonstrated improved liver tissue histology and function post-reperfusion with either the nitrite-supplemented preservation solution or in nitrite-treated recipients.
Interestingly, combined treatment of both the liver graft and recipient did not confer protection.
Thus, nitrite treatment affords significant protection from cold ischemic and reperfusion injury to donor livers and improves liver graft acute function post-transplantation.
The results from this study further support the potential for nitrite therapy to mitigate ischemia-reperfusion injury in solid organ transplantation.
American Psychological Association (APA)
Li, Wei& Meng, Zihui& Liu, Yuliang& Patel, Rakesh P.& Lang, John D.. 2012. The Hepatoprotective Effect of Sodium Nitrite on Cold Ischemia-Reperfusion Injury. Journal of Transplantation،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-486933
Modern Language Association (MLA)
Li, Wei…[et al.]. The Hepatoprotective Effect of Sodium Nitrite on Cold Ischemia-Reperfusion Injury. Journal of Transplantation No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-486933
American Medical Association (AMA)
Li, Wei& Meng, Zihui& Liu, Yuliang& Patel, Rakesh P.& Lang, John D.. The Hepatoprotective Effect of Sodium Nitrite on Cold Ischemia-Reperfusion Injury. Journal of Transplantation. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-486933
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-486933