Melanoma : From Melanocyte to Genetic Alterations and Clinical Options
Author
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-22, 22 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-12
Country of Publication
Egypt
No. of Pages
22
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Diseases
Abstract EN
Metastatic melanoma remained for decades without any effective treatment and was thus considered as a paradigm of cancer resistance.
Recent progress with understanding of the molecular mechanisms underlying melanoma initiation and progression revealed that melanomas are genetically and phenotypically heterogeneous tumors.
This recent progress has allowed for the development of treatment able to improve for the first time the overall disease-free survival of metastatic melanoma patients.
However, clinical responses are still either too transient or limited to restricted patient subsets.
The complete cure of metastatic melanoma therefore remains a challenge in the clinic.
This review aims to present the recent knowledge and discoveries of the molecular mechanisms involved in melanoma pathogenesis and their exploitation into clinic that have recently facilitated bench to bedside advances.
American Psychological Association (APA)
Bertolotto, Corine. 2013. Melanoma : From Melanocyte to Genetic Alterations and Clinical Options. Scientifica،Vol. 2013, no. 2013, pp.1-22.
https://search.emarefa.net/detail/BIM-486937
Modern Language Association (MLA)
Bertolotto, Corine. Melanoma : From Melanocyte to Genetic Alterations and Clinical Options. Scientifica No. 2013 (2013), pp.1-22.
https://search.emarefa.net/detail/BIM-486937
American Medical Association (AMA)
Bertolotto, Corine. Melanoma : From Melanocyte to Genetic Alterations and Clinical Options. Scientifica. 2013. Vol. 2013, no. 2013, pp.1-22.
https://search.emarefa.net/detail/BIM-486937
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-486937