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NNK-Induced Lung Tumors : A Review of Animal Model
Joint Authors
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-04-27
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The incidence of lung adenocarcinoma has been remarkably increasing in recent years due to the introduction of filter cigarettes and secondary-hand smoking because the people are more exposed to higher amounts of nitrogen oxides, especially 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone(NNK), which is widely applied in animal model of lung tumors.
In NNK-induced lung tumors, genetic mutation, chromosome instability, gene methylation, and activation of oncogenes have been found so as to disrupt the expression profiles of some proteins or enzymes in various cellular signal pathways.
Transgenic animal with specific alteration of lung cancer-related molecules have also been introduced to clarify the molecular mechanisms of NNK in the pathogenesis and development of lung tumors.
Based on these animal models, many antioxidant ingredients and antitumor chemotherapeutic agents have been proved to suppress the NNK-induced lung carcinogenesis.
In the future, it is necessary to delineate the most potent biomarkers of NNK-induced lung tumorigenesis, and to develop efficient methods to fight against NNK-associated lung cancer using animal models.
American Psychological Association (APA)
Zheng, Hua-Chuan& Takano, Yasuo. 2011. NNK-Induced Lung Tumors : A Review of Animal Model. Journal of Oncology،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-486955
Modern Language Association (MLA)
Zheng, Hua-Chuan& Takano, Yasuo. NNK-Induced Lung Tumors : A Review of Animal Model. Journal of Oncology No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-486955
American Medical Association (AMA)
Zheng, Hua-Chuan& Takano, Yasuo. NNK-Induced Lung Tumors : A Review of Animal Model. Journal of Oncology. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-486955
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-486955