Green Tea Extract Supplementation Induces the Lipolytic Pathway, Attenuates Obesity, and Reduces Low-Grade Inflammation in Mice Fed a High-Fat Diet
Joint Authors
de Souza, Cláudio T.
Neto, José César Rosa
Souza, Gabriel I. H.
Ribeiro, Eliane Beraldi
Rodrigues, Bruno
Sawaya, Alexandra Christine Helena Frankland
Cunha, Cláudio A.
da Silva, Camila Morais Gonçalves
Oller do Nascimento, Claudia Maria da Penha
Lira, Fabio Santos
Oyama, Lila Missae
de Oliveira Carvalho, Patrícia
Pimentel, Gustavo Duarte
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-01-29
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The aim of this study was to evaluate the effects of green tea Camellia sinensis extract on proinflammatory molecules and lipolytic protein levels in adipose tissue of diet-induced obese mice.
Animals were randomized into four groups: CW (chow diet and water); CG (chow diet and water + green tea extract); HW (high-fat diet and water); HG (high-fat diet and water + green tea extract).
The mice were fed ad libitum with chow or high-fat diet and concomitantly supplemented (oral gavage) with 400 mg/kg body weight/day of green tea extract (CG and HG, resp.).
The treatments were performed for eight weeks.
UPLC showed that in 10 mg/mL green tea extract, there were 15 μg/mg epigallocatechin, 95 μg/mg epigallocatechin gallate, 20.8 μg/mg epicatechin gallate, and 4.9 μg/mg gallocatechin gallate.
Green tea administered concomitantly with a high-fat diet increased HSL, ABHD5, and perilipin in mesenteric adipose tissue, and this was associated with reduced body weight and adipose tissue gain.
Further, we observed that green tea supplementation reduced inflammatory cytokine TNFα levels, as well as TLR4, MYD88, and TRAF6 proinflammatory signalling.
Our results show that green tea increases the lipolytic pathway and reduces adipose tissue, and this may explain the attenuation of low-grade inflammation in obese mice.
American Psychological Association (APA)
Cunha, Cláudio A.& Lira, Fabio Santos& Neto, José César Rosa& Pimentel, Gustavo Duarte& Souza, Gabriel I. H.& da Silva, Camila Morais Gonçalves…[et al.]. 2013. Green Tea Extract Supplementation Induces the Lipolytic Pathway, Attenuates Obesity, and Reduces Low-Grade Inflammation in Mice Fed a High-Fat Diet. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-486964
Modern Language Association (MLA)
Cunha, Cláudio A.…[et al.]. Green Tea Extract Supplementation Induces the Lipolytic Pathway, Attenuates Obesity, and Reduces Low-Grade Inflammation in Mice Fed a High-Fat Diet. Mediators of Inflammation No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-486964
American Medical Association (AMA)
Cunha, Cláudio A.& Lira, Fabio Santos& Neto, José César Rosa& Pimentel, Gustavo Duarte& Souza, Gabriel I. H.& da Silva, Camila Morais Gonçalves…[et al.]. Green Tea Extract Supplementation Induces the Lipolytic Pathway, Attenuates Obesity, and Reduces Low-Grade Inflammation in Mice Fed a High-Fat Diet. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-486964
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-486964