The Insulin and IGF-I Pathway in Endocrine Glands Carcinogenesis
Joint Authors
Belfiore, Antonino
Malaguarnera, Roberta
Morcavallo, Alaide
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-19, 19 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-08-08
Country of Publication
Egypt
No. of Pages
19
Main Subjects
Abstract EN
Endocrine cancers are a heterogeneous group of diseases that may arise from endocrine cells in any gland of the endocrine system.
These malignancies may show an aggressive behavior and resistance to the common anticancer therapies.
The etiopathogenesis of these tumors remains mostly unknown.
The normal embryological development and differentiation of several endocrine glands are regulated by specific pituitary tropins, which, in adult life, control the function and trophism of the endocrine gland.
Pituitary tropins act in concert with peptide growth factors, including the insulin-like growth factors (IGFs), which are considered key regulators of cell growth, proliferation, and apoptosis.
While pituitary TSH is regarded as tumor-promoting factor for metastatic thyroid cancer, the role of other pituitary hormones in endocrine cancers is uncertain.
However, multiple molecular abnormalities of the IGF system frequently occur in endocrine cancers and may have a role in tumorigenesis as well as in tumor progression and resistance to therapies.
Herein, we will review studies indicating a role of IGF system dysregulation in endocrine cancers and will discuss the possible implications of these findings for tumor prevention and treatment, with a major focus on cancers from the thyroid, adrenal, and ovary, which are the most extensively studied.
American Psychological Association (APA)
Malaguarnera, Roberta& Morcavallo, Alaide& Belfiore, Antonino. 2012. The Insulin and IGF-I Pathway in Endocrine Glands Carcinogenesis. Journal of Oncology،Vol. 2012, no. 2012, pp.1-19.
https://search.emarefa.net/detail/BIM-486971
Modern Language Association (MLA)
Malaguarnera, Roberta…[et al.]. The Insulin and IGF-I Pathway in Endocrine Glands Carcinogenesis. Journal of Oncology No. 2012 (2012), pp.1-19.
https://search.emarefa.net/detail/BIM-486971
American Medical Association (AMA)
Malaguarnera, Roberta& Morcavallo, Alaide& Belfiore, Antonino. The Insulin and IGF-I Pathway in Endocrine Glands Carcinogenesis. Journal of Oncology. 2012. Vol. 2012, no. 2012, pp.1-19.
https://search.emarefa.net/detail/BIM-486971
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-486971