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Regulation of Suppressors of Cytokine Signaling as a Therapeutic Approach in Autoimmune Diseases, with an Emphasis on Multiple Sclerosis
Joint Authors
Markovic-Plese, Silva
Ramgolam, Vinod S.
Source
Journal of Signal Transduction
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-11-01
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Multiple sclerosis (MS) is an inflammatory demyelinating, presumably autoimmune disease of the central nervous system (CNS).
Among the available MS therapies, interferon (IFN)β and the recently introduced statins have been reported to exert their immunomodulatory effects through the induction of SOCS1 and SOCS3 in various inflammatory cell subsets.
The SOCS proteins negatively regulate cytokine and Toll-like receptors- (TLR-) induced signaling in the inflammatory cells.
SOCS1 and SOCS3 have been reported to play an important role in the regulation of Th17-cell differentiation through their effects on the cells of the innate and adaptive immune systems.
IFNβ and statins inhibit Th17-cell differentiation directly and indirectly via induction of SOCS1 and SOCS3 expression in monocytes, dendritic cells (DCs), and B-cells.
Due to their rapid induction and degradation, and SOCS-mediated regulation of multiple cytokine-signaling pathways, they represent an attractive therapeutic target in the autoimmune diseases, and particularly relapsing remitting (RR) MS.
American Psychological Association (APA)
Ramgolam, Vinod S.& Markovic-Plese, Silva. 2011. Regulation of Suppressors of Cytokine Signaling as a Therapeutic Approach in Autoimmune Diseases, with an Emphasis on Multiple Sclerosis. Journal of Signal Transduction،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-486983
Modern Language Association (MLA)
Ramgolam, Vinod S.& Markovic-Plese, Silva. Regulation of Suppressors of Cytokine Signaling as a Therapeutic Approach in Autoimmune Diseases, with an Emphasis on Multiple Sclerosis. Journal of Signal Transduction No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-486983
American Medical Association (AMA)
Ramgolam, Vinod S.& Markovic-Plese, Silva. Regulation of Suppressors of Cytokine Signaling as a Therapeutic Approach in Autoimmune Diseases, with an Emphasis on Multiple Sclerosis. Journal of Signal Transduction. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-486983
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-486983