![](/images/graphics-bg.png)
ALS and Oxidative Stress : The Neurovascular Scenario
Joint Authors
Thakur, Keshav
Gupta, Pawan Kumar
Anand, Akshay
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-03
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Oxidative stress and angiogenic factors have been placed as the prime focus of scientific investigations after an establishment of link between vascular endothelial growth factor promoter (VEGF), hypoxia, and amyotrophic lateral sclerosis (ALS) pathogenesis.
Deletion of the hypoxia-response element in the vascular endothelial growth factor promoter and mutant superoxide dismutase 1 (SOD1) which are characterised by atrophy and muscle weakness resulted in phenotype resembling human ALS in mice.
This results in lower motor neurodegeneration thus establishing an important link between motor neuron degeneration, vasculature, and angiogenic molecules.
In this review, we have presented human, animal, and in vitro studies which suggest that molecules like VEGF have a therapeutic, diagnostic, and prognostic potential in ALS.
Involvement of vascular growth factors and hypoxia response elements also highlights the converging role of oxidative stress and neurovascular network for understanding and treatment of various neurodegenerative disorders like ALS.
American Psychological Association (APA)
Anand, Akshay& Thakur, Keshav& Gupta, Pawan Kumar. 2013. ALS and Oxidative Stress : The Neurovascular Scenario. Oxidative Medicine and Cellular Longevity،Vol. 2013, no. 2013, pp.1-14.
https://search.emarefa.net/detail/BIM-486993
Modern Language Association (MLA)
Anand, Akshay…[et al.]. ALS and Oxidative Stress : The Neurovascular Scenario. Oxidative Medicine and Cellular Longevity No. 2013 (2013), pp.1-14.
https://search.emarefa.net/detail/BIM-486993
American Medical Association (AMA)
Anand, Akshay& Thakur, Keshav& Gupta, Pawan Kumar. ALS and Oxidative Stress : The Neurovascular Scenario. Oxidative Medicine and Cellular Longevity. 2013. Vol. 2013, no. 2013, pp.1-14.
https://search.emarefa.net/detail/BIM-486993
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-486993