Peripheral Leukocyte Apoptosis in Patients with Parkinsonism : Correlation with Clinical Characteristics and Neuroimaging Findings
Joint Authors
Lin, Wei-Che
Kung, Chia-Te
Lin, Wei-Ming
Chen, Meng-Hsiang
Huang, Yung-Cheng
Li, Shau-Hsuan
Chen, Hsiu-Ling
Tsai, Nai-Wen
Lu, Cheng-Hsien
Su, Yu-Jih
Cheng, Kuei-Yueh
Chiu, Tsui-Min
Yang, I-Hsiao
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-25
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Apoptosis of both brain neurons and peripheral blood leukocyte is believed to be an important biomarker for evaluating the functional status of Parkinson’s disease (PD).
However, their correlation remains unknown.
A better understanding of the pathophysiology of neurodegeneration is essential for the treatment and prevention of PD.
The present study demonstrated that leukocyte apoptosis is significantly higher in PD patients and is associated with central dopamine neuron loss by using Tc99m-TRODAT-1 SPECT.
The leukocyte apoptosis and striatal dopamine transporter uptake ratios were further associated with increased severity and longer duration of disease.
The interaction between brain and systemic inflammation may be responsible for the neurodegenerative disease progression.
American Psychological Association (APA)
Lin, Wei-Che& Tsai, Nai-Wen& Huang, Yung-Cheng& Cheng, Kuei-Yueh& Chen, Hsiu-Ling& Li, Shau-Hsuan…[et al.]. 2014. Peripheral Leukocyte Apoptosis in Patients with Parkinsonism : Correlation with Clinical Characteristics and Neuroimaging Findings. BioMed Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-487001
Modern Language Association (MLA)
Lin, Wei-Che…[et al.]. Peripheral Leukocyte Apoptosis in Patients with Parkinsonism : Correlation with Clinical Characteristics and Neuroimaging Findings. BioMed Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-487001
American Medical Association (AMA)
Lin, Wei-Che& Tsai, Nai-Wen& Huang, Yung-Cheng& Cheng, Kuei-Yueh& Chen, Hsiu-Ling& Li, Shau-Hsuan…[et al.]. Peripheral Leukocyte Apoptosis in Patients with Parkinsonism : Correlation with Clinical Characteristics and Neuroimaging Findings. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-487001
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-487001