A Case of Inoperable Malignant Insulinoma with Resistant Hypoglycemia Who Experienced the Most Significant Clinical Improvement with Everolimus
Joint Authors
Andic, Cagatay
Bozkirli, Emre
Ertorer, Eda
Yapar, Ali Fuat
Bakiner, Okan
Abali, Huseyin
Kayaselcuk, Fazilet
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-05-08
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Metastatic insulinomas may sometimes present with recurrent life-threatening hypoglycemia episodes.
Such patients usually fail to respond to various therapeutic agents which causes constant dextrose infusion requirement.
Herein, we present a resistant case of inoperable malignant insulinoma who was treated with many therapeutic agents and interventions including somatostatin analogues, Yttrium-90 radioembolization, everolimus, radiotherapy, and chemoembolization.
Close blood sugar monitorization during these therapies showed the most favourable response with everolimus.
Everolimus treatment resulted in rapid improvement of hypoglycemia episodes, letting us discontinue dextrose infusion and discharge the patient.
However, experience with everolimus in such patients is still limited, and more precise data can be obtained with the increasing use of this agent for neuroendocrine tumours.
American Psychological Association (APA)
Bozkirli, Emre& Bakiner, Okan& Abali, Huseyin& Andic, Cagatay& Yapar, Ali Fuat& Kayaselcuk, Fazilet…[et al.]. 2013. A Case of Inoperable Malignant Insulinoma with Resistant Hypoglycemia Who Experienced the Most Significant Clinical Improvement with Everolimus. Case Reports in Endocrinology،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-487027
Modern Language Association (MLA)
Bozkirli, Emre…[et al.]. A Case of Inoperable Malignant Insulinoma with Resistant Hypoglycemia Who Experienced the Most Significant Clinical Improvement with Everolimus. Case Reports in Endocrinology No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-487027
American Medical Association (AMA)
Bozkirli, Emre& Bakiner, Okan& Abali, Huseyin& Andic, Cagatay& Yapar, Ali Fuat& Kayaselcuk, Fazilet…[et al.]. A Case of Inoperable Malignant Insulinoma with Resistant Hypoglycemia Who Experienced the Most Significant Clinical Improvement with Everolimus. Case Reports in Endocrinology. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-487027
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-487027