![](/images/graphics-bg.png)
Oxidative Damage, Inflammation, and Toll-Like Receptor 4 Pathway Are Increased in Preeclamptic Patients : A Case-Control Study
Joint Authors
Felisberto, Francine
de Souza, Cláudio T.
Bernardi, Fabiana C. B.
Dal-Pizzol, Felipe
Petronilho, Fabricia
Luciano, Thais F.
Vuolo, Francieli
Souza, Daniela R.
Ritter, Cristiane
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-24
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Problem.
There was no direct correlation between plasma and placental oxidative damage parameters and inflammation and evidence of TLR4 pathway activation in the placenta in preeclamptic (PE) patients.
Method of Study.
33 PE patients and 33 normotensive pregnant women were included.
The maternal section of the placenta and blood were collected to the determination of oxidative damage markers (thiobarbituric acid reactive species and protein carbonyls), inflammatory response (interleukin-6 and myeloperoxidase activity), and activation of the TLR-4-NF-kB pathway.
Results.
An increase of IL-6 levels in both plasma and placenta was observed, but myeloperoxidase activity was not significantly different comparing the groups.
Oxidative damage parameters were increased in plasma and placenta in PE patients.
A significant increase of the protein levels of TLR-4 and NF-kB was observed in the placenta.
Conclusion.
The TLR4-NF-kB pathway is upregulated in PE, probably generating local and systemic inflammatory response that is followed by local and systemic oxidative damage.
American Psychological Association (APA)
Bernardi, Fabiana C. B.& Felisberto, Francine& Vuolo, Francieli& Petronilho, Fabricia& Souza, Daniela R.& Luciano, Thais F.…[et al.]. 2012. Oxidative Damage, Inflammation, and Toll-Like Receptor 4 Pathway Are Increased in Preeclamptic Patients : A Case-Control Study. Oxidative Medicine and Cellular Longevity،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-487046
Modern Language Association (MLA)
Bernardi, Fabiana C. B.…[et al.]. Oxidative Damage, Inflammation, and Toll-Like Receptor 4 Pathway Are Increased in Preeclamptic Patients : A Case-Control Study. Oxidative Medicine and Cellular Longevity No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-487046
American Medical Association (AMA)
Bernardi, Fabiana C. B.& Felisberto, Francine& Vuolo, Francieli& Petronilho, Fabricia& Souza, Daniela R.& Luciano, Thais F.…[et al.]. Oxidative Damage, Inflammation, and Toll-Like Receptor 4 Pathway Are Increased in Preeclamptic Patients : A Case-Control Study. Oxidative Medicine and Cellular Longevity. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-487046
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-487046