MMSET : Role and Therapeutic Opportunities in Multiple Myeloma
Joint Authors
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-01
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Recurrent chromosomal translocations are central to the pathogenesis, diagnosis, and prognosis of hematologic malignancies.
The translocation t(4; 14)(p16; q32) is one of the most common translocations in multiple myeloma (MM) and is associated with very poor prognosis.
The t(4; 14) translocation leads to the simultaneous overexpression of two genes, FGFR3 (fibroblast growth factor receptor 3) and MMSET (multiple myeloma SET domain), both of which have potential oncogenic activity.
However, approximately 30% of t(4; 14) MM patients do not express FGFR3 and have poor prognosis irrespective of FGFR3 expression, whereas MMSET overexpression is universal in t(4; 14) cases.
In this review, we provide an overview of recent findings regarding the oncogenic roles of MMSET in MM and its functions on histone methylation.
We also highlight some of MMSET partners and its downstream signalling pathways and discuss the potential therapeutics targeting MMSET.
American Psychological Association (APA)
Xie, Zhigang& Chng, Wee Joo. 2014. MMSET : Role and Therapeutic Opportunities in Multiple Myeloma. BioMed Research International،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-487056
Modern Language Association (MLA)
Xie, Zhigang& Chng, Wee Joo. MMSET : Role and Therapeutic Opportunities in Multiple Myeloma. BioMed Research International No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-487056
American Medical Association (AMA)
Xie, Zhigang& Chng, Wee Joo. MMSET : Role and Therapeutic Opportunities in Multiple Myeloma. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-487056
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-487056