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Primary Leiomyosarcoma of Bone : Analysis of Prognosis
Joint Authors
Carter, Simon R.
Abudu, Adesegun
Sumathi, Vaiyapuri
Brewer, P.
Tillman, Roger M.
Jeys, L. M.
Grimer, Robert J.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-11
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Leiomyosarcoma of bone is just one of the variants of spindle cell sarcoma of bone characterised by the expression of desmin and other markers indicating a significant element of smooth muscle in the tumour, without osteoid production we have investigated the management and outcome of this rare type of primary malignant bone tumour.
Method.
Retrospective review of data stored on a prospective database.
Results.
In a database of 3364 patients with primary malignant bone sarcomas, 31 patients were identified with a primary leiomyosarcoma of bone.
There were 12 males and 19 females with a mean age of 46 and tumour size of 8 cm.
The most common site was the distal femur followed by the proximal tibia.
Treatment was with chemotherapy and surgical resection.
Seven of the patients had metastases at diagnosis.
Surgery was carried out in 28 patients, 8 having amputation and 20 limb salvage.
Three patients developed local recurrence, but half developed metastases.
All patient disease-specific survival was 57% at five years and 44% at 10 yrs but for those without metastases was 82% and 60%, respectively.
The only prognostic factors were metastases at diagnosis.
Conclusion.
Leiomyosarcoma of bone is a very rare primary malignant bone tumour affecting a predominantly older population.
Despite the high incidence of metastases, survival is better than for other bone sarcomas for those without metastases at diagnosis.
American Psychological Association (APA)
Brewer, P.& Sumathi, Vaiyapuri& Grimer, Robert J.& Carter, Simon R.& Tillman, Roger M.& Abudu, Adesegun…[et al.]. 2012. Primary Leiomyosarcoma of Bone : Analysis of Prognosis. Sarcoma،Vol. 2012, no. 2012, pp.1-4.
https://search.emarefa.net/detail/BIM-487082
Modern Language Association (MLA)
Brewer, P.…[et al.]. Primary Leiomyosarcoma of Bone : Analysis of Prognosis. Sarcoma No. 2012 (2012), pp.1-4.
https://search.emarefa.net/detail/BIM-487082
American Medical Association (AMA)
Brewer, P.& Sumathi, Vaiyapuri& Grimer, Robert J.& Carter, Simon R.& Tillman, Roger M.& Abudu, Adesegun…[et al.]. Primary Leiomyosarcoma of Bone : Analysis of Prognosis. Sarcoma. 2012. Vol. 2012, no. 2012, pp.1-4.
https://search.emarefa.net/detail/BIM-487082
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-487082