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Bedtime Single-Dose Prednisolone in Clinically Stable Rheumatoid Arthritis Patients
Joint Authors
Mosadegh Moneyreh, Modares
Bagher, Owlia Mohammad
Golbarg, Mehrpoor
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-05
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Pharmacy, Health & Medical Sciences
Pharmacology
Abstract EN
Introduction.
Sign and symptoms of rheumatoid arthritis have circadian rhythms and are more prominent in the morning.
Timing of glucocorticoid administration may be important with respect to the natural secretion of endogenous glucocorticoids.
Herein, we intended to test the hypothesis that bedtime administration of prednisolone could be more efficient in controlling signs and symptoms in patients with RA.
Material and Methods.
Sixty patients with stable disease were treated with single dose prednisolone at 8 a.m.
for the first three months and thereafter with similar dose at 10 PM for the next three months (before-after method).
We compared fatigue scores, morning stiffness and pain scores, Clinical Disease Activity Indices, erythrocyte sedimentation rates, C Reactive Protein, and profile of adverse effects.
Results.
The mean of morning stiffness, fatigue scores, CRP and CDAI decreased statistically when prednisolone was administrated at 10 p.m.
The means of pain scores and ESR were also decreased when the patients took prednisolone at night, without significant statistical difference.
Conclusion.
Administration of low-dose oral prednisolone could reduce disease activity scores in morning in clinically stable patients with RA.
So it could be supposed that administrating bedtime prednisolone may permit the smallest possible dose.Erratum to “Bedtime Single-Dose Prednisolone in Clinically Stable Rheumatoid Arthritis Patients”dx.doi.org/10.5402/2012/521976
American Psychological Association (APA)
Bagher, Owlia Mohammad& Golbarg, Mehrpoor& Mosadegh Moneyreh, Modares. 2012. Bedtime Single-Dose Prednisolone in Clinically Stable Rheumatoid Arthritis Patients. ISRN Pharmacology،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-487113
Modern Language Association (MLA)
Bagher, Owlia Mohammad…[et al.]. Bedtime Single-Dose Prednisolone in Clinically Stable Rheumatoid Arthritis Patients. ISRN Pharmacology No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-487113
American Medical Association (AMA)
Bagher, Owlia Mohammad& Golbarg, Mehrpoor& Mosadegh Moneyreh, Modares. Bedtime Single-Dose Prednisolone in Clinically Stable Rheumatoid Arthritis Patients. ISRN Pharmacology. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-487113
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-487113