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Pan-PPAR Agonist, Bezafibrate, Restores Angiogenesis in Hindlimb Ischemia in Normal and Diabetic Rats
Joint Authors
Rashidi, B.
Salehi, E.
Khazaei, Majid
Source
International Journal of Peptides
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-03
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Introduction.
The aim of this study was to investigate the effect of bezafibrate as a pan-PPAR agonist on angiogenesis and serum nitrite, the main metabolite of nitric oxide (NO), vascular endothelial growth factor (VEGF) and VEGF receptor-2 (VEGFR-2) concentrations in hindlimb ischemia model of normal and type I diabetic rats.
Methods.
28 male Wistar rats were divided into control and diabetic groups.
Then, all rats underwent unilateral hindlimb ischemia.
After recovery, they were randomly assigned to one of the following experimental groups: (1) control; (2) control + bezafibrate (400 mg/kg/day); (3) diabetic; (4) diabetic + beztafibrate.
After three weeks, blood samples were taken and capillary density was evaluated in the gasterocnemius muscle of ischemic limb.
Results.
Bezafibrate increased capillary density and capillary/fiber ratio in ischemic leg of diabetic and control rats (P<0.05).
Serum VEGF and VEGFR-2 concentrations did not alter after bezafibrate administration, however, serum nitrite concentration was significantly higher in bezafibrate-treated groups than non-treated groups (P<0.05).
Discussion.
It seems that bezafibrate, as a pan PPAR agonist, restores angiogenesis in hindlimb ischemic diabetic animals and is useful for prevention and/or treatment of peripheral artery disease in diabetic subjects.
American Psychological Association (APA)
Khazaei, Majid& Salehi, E.& Rashidi, B.. 2012. Pan-PPAR Agonist, Bezafibrate, Restores Angiogenesis in Hindlimb Ischemia in Normal and Diabetic Rats. International Journal of Peptides،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-487116
Modern Language Association (MLA)
Khazaei, Majid…[et al.]. Pan-PPAR Agonist, Bezafibrate, Restores Angiogenesis in Hindlimb Ischemia in Normal and Diabetic Rats. International Journal of Peptides No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-487116
American Medical Association (AMA)
Khazaei, Majid& Salehi, E.& Rashidi, B.. Pan-PPAR Agonist, Bezafibrate, Restores Angiogenesis in Hindlimb Ischemia in Normal and Diabetic Rats. International Journal of Peptides. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-487116
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-487116