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Langerhans Cell Histiocytosis Presenting as Uncontrolled Asthma
Joint Authors
Hull, James E.
Morgan, Julia A.
Rawlins, Frederic A.
Morris, Michael J.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-08-27
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Langerhans cell histiocytosis (LCH) is an uncommon disorder affecting primarily young adult smokers.
It is characterized by abnormal proliferation of Langerhans cells, specialized monocyte-macrophage lineage antigen-presenting cells.
LCH can affect the lungs in isolation or as part of a systemic disease.
Most commonly, the disease presents in the third or fourth decade without gender predominance.
Symptoms typically include dyspnea and cough.
Commonly, physical examination is unremarkable but cor pulmonale may be observed in advanced disease.
The chest radiograph is typically abnormal with nodular or interstitial infiltrates and cystic changes.
High-resolution computed tomography of the chest with these findings in the middle and upper lobes of an adult smoker is virtually diagnostic of LCH.
Pulmonary function assessment is variable.
Asthma has rarely been reported in association with this disorder.
There are only three reported cases of the diagnosis of concomitant asthma which have been made in association with the diagnosis of LCH.
We present a case in which our patient presented with signs and symptoms of asthma to include confirmatory findings of airway hyperresponsiveness.
The diagnosis of LCH was established after the patient failed to respond to conventional treatment for asthma, and further evaluation was completed.
American Psychological Association (APA)
Rawlins, Frederic A.& Hull, James E.& Morgan, Julia A.& Morris, Michael J.. 2013. Langerhans Cell Histiocytosis Presenting as Uncontrolled Asthma. Case Reports in Medicine،Vol. 2013, no. 2013, pp.1-4.
https://search.emarefa.net/detail/BIM-487117
Modern Language Association (MLA)
Rawlins, Frederic A.…[et al.]. Langerhans Cell Histiocytosis Presenting as Uncontrolled Asthma. Case Reports in Medicine No. 2013 (2013), pp.1-4.
https://search.emarefa.net/detail/BIM-487117
American Medical Association (AMA)
Rawlins, Frederic A.& Hull, James E.& Morgan, Julia A.& Morris, Michael J.. Langerhans Cell Histiocytosis Presenting as Uncontrolled Asthma. Case Reports in Medicine. 2013. Vol. 2013, no. 2013, pp.1-4.
https://search.emarefa.net/detail/BIM-487117
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-487117