HS1,2 Ig Enhancer Alleles Association to AIDS Progression in a Pediatric Cohort Infected with a Monophyletic HIV-Strain
Joint Authors
Mancino, Giorgio
Palma, Paolo
Frezza, Domenico
Amicosante, Massimo
Gattinara, Guido Castelli
Mattei, Maurizio
Montesano, Carla
Colizzi, Vittorio
Serone, Eliseo
Giambra, Vincenzo
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-20
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Alteration in the humoral immune response has been observed during HIV infection.
The polymorphisms of enhancer HS1,2, member of the 3′ regulatory region of the Ig heavy chain cluster, may play a role in the variation of the humoral response leading to pathological conditions.
To assess the role of the HS1,2 polymorphic variants in the progression of AIDS, the HS1,2-A allelic frequencies were investigated in a cohort of HIV infected pediatric subjects from a nosocomial outbreak with a monophyletic strain of HIV.
From a total group of 418 HIV infected children in the outbreak cohort, 42 nonprogressors and 31 progressors without bias due to antiretroviral therapy were evaluated.
HS1,2 allele *1 has been associated with nonprogressors (allelic frequency: 51.19% versus 33.87% in progressors, OR 0.5, and P=0.0437), while allele *2 has been associated with progression (allelic frequency: 48.39% versus 30.95% in nonprogressors, OR 2.1, and P=0.0393).
Further, only subjects carrying allele *2 in absence of allele *1, either in homozygous condition for allele *2 [nonprogressors 2/42 (4.76%), Progressors 7/31 (22.58%), OR 5.8, and P=0.0315] or in combination with other allelic variants [nonprogressors 7/42 (16.67%), Progressors 13/31 (41.93%), OR 3.61, and P=0.0321], have been associated with HIV progression to AIDS.
In conclusion, while the HS1,2 allele *1 has a protective effect on HIV progression when present, allele *2 is associated with progression toward AIDS when allele *1 is absent.
American Psychological Association (APA)
Montesano, Carla& Giambra, Vincenzo& Frezza, Domenico& Palma, Paolo& Serone, Eliseo& Gattinara, Guido Castelli…[et al.]. 2014. HS1,2 Ig Enhancer Alleles Association to AIDS Progression in a Pediatric Cohort Infected with a Monophyletic HIV-Strain. BioMed Research International،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-487146
Modern Language Association (MLA)
Montesano, Carla…[et al.]. HS1,2 Ig Enhancer Alleles Association to AIDS Progression in a Pediatric Cohort Infected with a Monophyletic HIV-Strain. BioMed Research International No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-487146
American Medical Association (AMA)
Montesano, Carla& Giambra, Vincenzo& Frezza, Domenico& Palma, Paolo& Serone, Eliseo& Gattinara, Guido Castelli…[et al.]. HS1,2 Ig Enhancer Alleles Association to AIDS Progression in a Pediatric Cohort Infected with a Monophyletic HIV-Strain. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-487146
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-487146