Effects of Olopatadine Hydrochloride, a Histamine H1 Receptor Antagonist, on Histamine-Induced Skin Responses
Joint Authors
Karashima, Tadashi
Hamada, Takahiro
Dainichi, Teruki
Nakama, Takekuni
Ishii, Norito
Hashimoto, Takashi
Yasumoto, Shinichiro
Source
Dermatology Research and Practice
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-09-16
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Effects of olopatadine hydrochloride, a histamine H1 receptor antagonist, on histamine-induced skin responses were evaluated in 10 healthy subjects in comparison with placebo, fexofenadine hydrochloride, and bepotastine besilate.
Olopatadine significantly suppressed histamine-induced wheal, flare, and itch, starting 30 minutes after oral administration.
Olopatadine was more effective than fexofenadine and bepotastine.
None of the drugs studied impaired performance of word processing tasks.
These results suggest that olopatadine can suppress skin symptoms caused by histamine soon after administration.
American Psychological Association (APA)
Hashimoto, Takashi& Ishii, Norito& Hamada, Takahiro& Dainichi, Teruki& Karashima, Tadashi& Nakama, Takekuni…[et al.]. 2010. Effects of Olopatadine Hydrochloride, a Histamine H1 Receptor Antagonist, on Histamine-Induced Skin Responses. Dermatology Research and Practice،Vol. 2010, no. 2010, pp.1-4.
https://search.emarefa.net/detail/BIM-487195
Modern Language Association (MLA)
Hashimoto, Takashi…[et al.]. Effects of Olopatadine Hydrochloride, a Histamine H1 Receptor Antagonist, on Histamine-Induced Skin Responses. Dermatology Research and Practice No. 2010 (2010), pp.1-4.
https://search.emarefa.net/detail/BIM-487195
American Medical Association (AMA)
Hashimoto, Takashi& Ishii, Norito& Hamada, Takahiro& Dainichi, Teruki& Karashima, Tadashi& Nakama, Takekuni…[et al.]. Effects of Olopatadine Hydrochloride, a Histamine H1 Receptor Antagonist, on Histamine-Induced Skin Responses. Dermatology Research and Practice. 2010. Vol. 2010, no. 2010, pp.1-4.
https://search.emarefa.net/detail/BIM-487195
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-487195
