Fragility of Bioprotectant Glass-Forming Systems in Extremophiles

Joint Authors

Magazù, Salvatore
Migliardo, F.

Source

Journal of Atomic, Molecular, and Optical Physics

Issue

Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-9, 9 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2009-06-04

Country of Publication

Egypt

No. of Pages

9

Main Subjects

Physics

Abstract EN

A central issue in the adaptation of proteins and enzymes to extreme conditions is the conservation of their functional state, which is characterized by a well-balanced compromise of stability and flexibility.

In this review work an overview of elastic neutron scattering (ENS) findings on a class of bioprotectant glass-forming systems, such as trehalose and its homologous (maltose and sucrose) water mixtures, is presented as a function of temperature and concentration.

ENS, in fact, allows to determine some remarkable quantities in order to characterize the correlation among dynamical properties, the flexibility and fragility of biomolecules.

The experimental results have pointed out a dynamical transition, which shows a crossover in molecular fluctuations between harmonic and anharmonic dynamical regimes.

The ENS findings allow to characterize both the trehalose rigidity and flexibility, which are strictly connected to its superior bioprotective effectiveness.

In this frame the lowest flexibility and fragility character of trehalose/H2O mixture with respect to maltose and sucrose/H2O mixtures indicate a better attitude to encapsulate biostructures in more rigid and temperature insensitive structures in approaching the glass transition.

American Psychological Association (APA)

Magazù, Salvatore& Migliardo, F.. 2009. Fragility of Bioprotectant Glass-Forming Systems in Extremophiles. Journal of Atomic, Molecular, and Optical Physics،Vol. 2009, no. 2009, pp.1-9.
https://search.emarefa.net/detail/BIM-487199

Modern Language Association (MLA)

Magazù, Salvatore& Migliardo, F.. Fragility of Bioprotectant Glass-Forming Systems in Extremophiles. Journal of Atomic, Molecular, and Optical Physics No. 2009 (2009), pp.1-9.
https://search.emarefa.net/detail/BIM-487199

American Medical Association (AMA)

Magazù, Salvatore& Migliardo, F.. Fragility of Bioprotectant Glass-Forming Systems in Extremophiles. Journal of Atomic, Molecular, and Optical Physics. 2009. Vol. 2009, no. 2009, pp.1-9.
https://search.emarefa.net/detail/BIM-487199

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-487199