The Efficacy of Nebulized Furosemide and Salbutamol Compared with Salbutamol Alone in Reactive Airway Disease : A Double Blind Randomized, Clinical Trial
Joint Authors
Feli, Maryam
Forouzan, Arash
Porozan, Samaneh
Haddadzadeh Shoushtari, Maryam
Fallah Bagher Sheidaee, Mehdi
Asgari Darian, Ali
Masoumi, Kambiz
Source
Emergency Medicine International
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-27
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
We undertook this randomized clinical trial to investigate whether adding furosemide to salbutamol could improve the peak expiratory flow rate (PEFR) and clinical signs of reactive airway disease (RAD) patients.
Eligible 18- to 55-year-old patients were randomly divided into intervention and control groups.
Patients received 5 mg of nebulized salbutamol and 40 mg of nebulized furosemide in the intervention group and 5 mg of nebulized salbutamol alone in the control group.
Patients in both groups received 100 mg of methylprednisolone intravenously stat.
Severity of the RAD was estimated before and 45 minutes after treatment in both groups.
PEFR was estimated before treatment and at 15, 30, and 45 minutes later.
Ninety patients were enrolled, 45 in each group.
There were no significant differences between two groups regarding gender, mean age, and normalized PEFR.
The baseline mean PEFR was not significantly different between groups (P=0.58).
A repeated measure analysis of variance revealed that the differences between the two treatments was significant (P=0.0001) and the behavior of two treatments was not similar across the time (P=0.001).
Comparison of clinical severity of acute RAD revealed no significant differences between groups at the end of the trial (0.06).
This study showed that adding nebulized furosemide to salbutamol in RAD patients improved PEFR.
American Psychological Association (APA)
Masoumi, Kambiz& Forouzan, Arash& Haddadzadeh Shoushtari, Maryam& Porozan, Samaneh& Feli, Maryam& Fallah Bagher Sheidaee, Mehdi…[et al.]. 2014. The Efficacy of Nebulized Furosemide and Salbutamol Compared with Salbutamol Alone in Reactive Airway Disease : A Double Blind Randomized, Clinical Trial. Emergency Medicine International،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-487205
Modern Language Association (MLA)
Masoumi, Kambiz…[et al.]. The Efficacy of Nebulized Furosemide and Salbutamol Compared with Salbutamol Alone in Reactive Airway Disease : A Double Blind Randomized, Clinical Trial. Emergency Medicine International No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-487205
American Medical Association (AMA)
Masoumi, Kambiz& Forouzan, Arash& Haddadzadeh Shoushtari, Maryam& Porozan, Samaneh& Feli, Maryam& Fallah Bagher Sheidaee, Mehdi…[et al.]. The Efficacy of Nebulized Furosemide and Salbutamol Compared with Salbutamol Alone in Reactive Airway Disease : A Double Blind Randomized, Clinical Trial. Emergency Medicine International. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-487205
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-487205