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Association of Obesity with Proteasomal Gene Polymorphisms in Children
Joint Authors
Sugoka, Olga
Paramonova, Natalija
Kupca, Sarmite
Trapina, Ilva
Sipols, Alfred J.
Daugule, Ilva
Rinkuza, Irena
Sjakste, Tatjana
Rumba-Rozenfelde, Ingrida
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-21
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The aim of this study was to ascertain possible associations between childhood obesity, its anthropometric and clinical parameters, and three loci of proteasomal genes rs2277460 (PSMA6 c.-110C>A), rs1048990 (PSMA6 c.-8C>G), and rs2348071 (PSMA3 c.
543+138G>A) implicated in obesity-related diseases.
Obese subjects included 94 otherwise healthy children in Latvia.
Loci were genotyped and then analyzed using polymerase chain reactions, with results compared to those of 191 nonobese controls.
PSMA3 SNP frequency differences between obese children and controls, while not reaching significance, suggested a trend.
These differences, however, proved highly significant (P<0.002) in the subset of children reporting a family history of obesity.
Among obese children denying such history, PSMA6 c.-8C>G SNP differences, while being nonsignificant, likewise suggested a trend in comparison to the nonobese controls.
No PSMA6 c.-110C>A SNP differences were detected in the obese group or its subsets.
Finally, PSMA3 SNP differences were significantly associated (P<0.05) with circulating low-density lipoprotein cholesterol (LDL) levels.
Our results clearly implicate the PSMA3 gene locus as an obesity risk factor in those Latvian children with a family history of obesity.
While being speculative, the clinical results are suggestive of altered circulatory LDL levels playing a possible role in the etiology of obesity in the young.
American Psychological Association (APA)
Kupca, Sarmite& Sjakste, Tatjana& Paramonova, Natalija& Sugoka, Olga& Rinkuza, Irena& Trapina, Ilva…[et al.]. 2013. Association of Obesity with Proteasomal Gene Polymorphisms in Children. Journal of Obesity،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-487210
Modern Language Association (MLA)
Kupca, Sarmite…[et al.]. Association of Obesity with Proteasomal Gene Polymorphisms in Children. Journal of Obesity No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-487210
American Medical Association (AMA)
Kupca, Sarmite& Sjakste, Tatjana& Paramonova, Natalija& Sugoka, Olga& Rinkuza, Irena& Trapina, Ilva…[et al.]. Association of Obesity with Proteasomal Gene Polymorphisms in Children. Journal of Obesity. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-487210
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-487210