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Immunopathogenic Role of Herpes Simplex Virus in Behçet’s Disease
Joint Authors
Bang, Dongsik
Sohn, Seonghyang
Lee, Eun-So
Choi, Min Ju
Kim, Do Young
Cho, Suhyun
Source
Genetics Research International
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-24
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The role of viral infections, such as herpes simplex virus (HSV) infection, in the pathogenesis of Behçet’s disease (BD) has been investigated for many years.
HSV has been detected in peripheral blood leukocytes, saliva, and genital ulcers of patients with BD.
Various cell adhesion molecules on cultured endothelial cells have been induced by HSV in a TNF-α dependent manner.
In addition, a BD-like animal model was developed by inoculating ICR mouse earlobes with HSV, and antiviral treatment was effective in improving BD-like symptoms in this model.
Still, there are several incompletely characterized proteins that possess antiviral properties and are being investigated as mediators of viral infection-related chronic inflammatory reactions.
Although the role of HSV in the pathogenesis of BD remains to be fully established, recent research findings regarding HSV in BD have expanded our understanding of the disease and will hopefully lead to the development of more effective therapeutic agents in the near future.
American Psychological Association (APA)
Kim, Do Young& Cho, Suhyun& Choi, Min Ju& Sohn, Seonghyang& Lee, Eun-So& Bang, Dongsik. 2013. Immunopathogenic Role of Herpes Simplex Virus in Behçet’s Disease. Genetics Research International،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-487229
Modern Language Association (MLA)
Kim, Do Young…[et al.]. Immunopathogenic Role of Herpes Simplex Virus in Behçet’s Disease. Genetics Research International No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-487229
American Medical Association (AMA)
Kim, Do Young& Cho, Suhyun& Choi, Min Ju& Sohn, Seonghyang& Lee, Eun-So& Bang, Dongsik. Immunopathogenic Role of Herpes Simplex Virus in Behçet’s Disease. Genetics Research International. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-487229
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-487229