Neuroinflammation Screening in Immunotherapy Trials against Alzheimer's Disease
Joint Authors
Zetterberg, Henrik
Blennow, kaj
Andreasen, Niels
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-3, 3 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-12-19
Country of Publication
Egypt
No. of Pages
3
Main Subjects
Abstract EN
Due to side effects in the form of meningoencephalitis in the interrupted phase II AN1792 trial of active antiamyloid β(Aβ) immunization against Alzheimer's disease (AD), there has been concern that anti-Aβ immunization may cause destructive neuroinflammation.
Here, we report on two patients fulfilling clinical AD criteria who were diagnosed with Lyme neuroborreliosis during screening before inclusion in anti-Aβ immunotherapy trials.
The two cases illustrate the necessity of careful biochemical screening for neuroinflammatory/neuroinfectious conditions before an AD diagnosis is made and before clinical AD patients are included in trials of therapy that could impact the immune system.
Should the two cases have been included and deteriorated, additional investigations might have led to the erroneous conclusion that therapy-induced meningoencephalitis had occurred.
American Psychological Association (APA)
Andreasen, Niels& Blennow, kaj& Zetterberg, Henrik. 2010. Neuroinflammation Screening in Immunotherapy Trials against Alzheimer's Disease. International Journal of Alzheimer's Disease،Vol. 2010, no. 2010, pp.1-3.
https://search.emarefa.net/detail/BIM-487237
Modern Language Association (MLA)
Andreasen, Niels…[et al.]. Neuroinflammation Screening in Immunotherapy Trials against Alzheimer's Disease. International Journal of Alzheimer's Disease No. 2010 (2010), pp.1-3.
https://search.emarefa.net/detail/BIM-487237
American Medical Association (AMA)
Andreasen, Niels& Blennow, kaj& Zetterberg, Henrik. Neuroinflammation Screening in Immunotherapy Trials against Alzheimer's Disease. International Journal of Alzheimer's Disease. 2010. Vol. 2010, no. 2010, pp.1-3.
https://search.emarefa.net/detail/BIM-487237
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-487237