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Synthesis, Characterization, and Biological Activity of Novel Schiff and Mannich Bases of 4-Amino-3-(N-phthalimidomethyl)-1,2,4-triazole-5-thione
Joint Authors
Mussarat, Nosheen
Rahman, Naima
Asghar, Shazia
Bhatti, Moazzam H.
Masood, Bilal
Yunus, Uzma
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-06
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The present work describes the syntheses and antimicrobial activity studies of a series of novel Schiff bases (4a–4i) and their Mannich bases (5a–5h) starting from 4-amino-3-(N-phthalimido-methyl)-1,2,4-triazole-5-thione (3).
All the synthesized compounds were characterized by IR, 1H-NMR, 13C-NMR, and MS.
All the synthesized compounds were screened for four Gram-negative strains, one Gram-positive strain of bacteria, and one diploid fungal strain.
In general the antimicrobial activity increased remarkably on the introduction of azomethine functionality in parent triazole (3).
The antimicrobial activity further improved when morpholine group was added to them except for Enterobacter cloacae, where loss of activity was observed.
The results are promising and show that the fine tuning of the structures (5a, 5b, 5e, 5f, and 5h) can lead to some new antimicrobial compounds.
American Psychological Association (APA)
Yunus, Uzma& Bhatti, Moazzam H.& Rahman, Naima& Mussarat, Nosheen& Asghar, Shazia& Masood, Bilal. 2013. Synthesis, Characterization, and Biological Activity of Novel Schiff and Mannich Bases of 4-Amino-3-(N-phthalimidomethyl)-1,2,4-triazole-5-thione. Journal of Chemistry،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-487256
Modern Language Association (MLA)
Yunus, Uzma…[et al.]. Synthesis, Characterization, and Biological Activity of Novel Schiff and Mannich Bases of 4-Amino-3-(N-phthalimidomethyl)-1,2,4-triazole-5-thione. Journal of Chemistry No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-487256
American Medical Association (AMA)
Yunus, Uzma& Bhatti, Moazzam H.& Rahman, Naima& Mussarat, Nosheen& Asghar, Shazia& Masood, Bilal. Synthesis, Characterization, and Biological Activity of Novel Schiff and Mannich Bases of 4-Amino-3-(N-phthalimidomethyl)-1,2,4-triazole-5-thione. Journal of Chemistry. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-487256
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-487256