The Role of Uric Acid in Kidney Fibrosis : Experimental Evidences for the Causal Relationship
Joint Authors
Kwak, Ihm Soo
Lee, Soo Bong
Lee, Dong Won
Kim, Il Young
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-05
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Hyperuricemia is a common finding in chronic kidney disease due to decreased uric acid clearance.
The role of uric acid as a risk factor for chronic kidney disease has been largely debated, and recent studies suggested a role of uric acid in the causation and progression of kidney fibrosis, a final common pathway in chronic kidney disease.
Uric acid and xanthine oxidase may contribute to kidney fibrosis mainly by inducing inflammation, endothelial dysfunction, oxidative stress, and activation of the renin-angiotensin system.
Besides, hyperuricemia induces alterations in renal hemodynamics via afferent arteriolopathy and contributes to the onset and progression of kidney fibrosis.
Xanthine oxidase inhibitors may prevent kidney damage via lowering uric acid and/or inhibiting xanthine oxidase.
However, there is still no sufficient evidence from interventional clinical researches supporting the causal relationship between uric acid and kidney fibrosis.
The effect and role of xanthine oxidase inhibitors in preventing kidney fibrosis and chronic kidney disease progression must be further explored by performing future large scale clinical trials.
American Psychological Association (APA)
Kim, Il Young& Lee, Dong Won& Lee, Soo Bong& Kwak, Ihm Soo. 2014. The Role of Uric Acid in Kidney Fibrosis : Experimental Evidences for the Causal Relationship. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-487271
Modern Language Association (MLA)
Kim, Il Young…[et al.]. The Role of Uric Acid in Kidney Fibrosis : Experimental Evidences for the Causal Relationship. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-487271
American Medical Association (AMA)
Kim, Il Young& Lee, Dong Won& Lee, Soo Bong& Kwak, Ihm Soo. The Role of Uric Acid in Kidney Fibrosis : Experimental Evidences for the Causal Relationship. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-487271
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-487271