Alternative Splicing in Oncogenic Kinases : From Physiological Functions to Cancer
Joint Authors
Druillennec, Sabine
Eychène, Alain
Dorard, Coralie
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-05
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Among the 518 protein kinases encoded by the human kinome, several of them act as oncoproteins in human cancers.
Like other eukaryotic genes, oncogenes encoding protein kinases are frequently subjected to alternative splicing in coding as well as noncoding sequences.
In the present paper, we will illustrate how alternative splicing can significantly impact on the physiological functions of oncogenic protein kinases, as demonstrated by mouse genetic model studies.
This includes examples of membrane-bound tyrosine kinases receptors (FGFR2, Ret, TrkB, ErbB4, and VEGFR) as well as cytosolic protein kinases (B-Raf).
We will further discuss how regular alternative splicing events of these kinases are in some instances implicated in oncogenic processes during tumor progression (FGFR, TrkB, ErbB2, Abl, and AuroraA).
Finally, we will present typical examples of aberrant splicing responsible for the deregulation of oncogenic kinases activity in cancers (AuroraB, Jak2, Kit, Met, and Ron).
American Psychological Association (APA)
Druillennec, Sabine& Dorard, Coralie& Eychène, Alain. 2011. Alternative Splicing in Oncogenic Kinases : From Physiological Functions to Cancer. Journal of Nucleic Acids،Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-487289
Modern Language Association (MLA)
Druillennec, Sabine…[et al.]. Alternative Splicing in Oncogenic Kinases : From Physiological Functions to Cancer. Journal of Nucleic Acids No. 2012 (2012), pp.1-14.
https://search.emarefa.net/detail/BIM-487289
American Medical Association (AMA)
Druillennec, Sabine& Dorard, Coralie& Eychène, Alain. Alternative Splicing in Oncogenic Kinases : From Physiological Functions to Cancer. Journal of Nucleic Acids. 2011. Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-487289
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-487289